Marley Dewey

About

Dr. Marley Dewey is an Assistant Professor in the Department of Biological Engineering at the University of California, Santa Barbara. Her research focuses on engineering biomaterials with extracellular vesicles towards skeletal repair. Specifically, her lab investigates a new class of extracellular vesicle residing in the extracellular matrix, termed matrix-bound nanovesicles. Her work aims to answer basic science questions and create translational therapies related to bone cancer, improving bone repair, preventing bone infection, and repairing coral reefs. Dr. Dewey completed her B.S. in Chemical Engineering at the University of Maine in 2012 and earned her PhD in Materials Science and Engineering at the University of Illinois Urbana-Champaign, where she worked in the laboratory of Dr. Brendan Harley. During her graduate studies, she modified the mechanical, immunological, osteogenic, and antimicrobial properties of mineralized collagen scaffolds for enhanced repair of large-scale craniomaxillofacial bone defects. She was recognized with various awards, including the Annual Innovation Award for Outstanding PhD Thesis and was a National Science Foundation Graduate Research Fellow. Following her PhD, she completed postdoctoral work in the laboratory of Dr. Stephen Badylak at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. As a postdoc, she was awarded an NIH TL1 Clinical and Translational Science Fellowship for her research on a new class of…

Research topics

• Biomedical engineering
• Computer Science
• Cell biology
• Medicine
• Chemistry
• Biology
• Immunology
• Biochemistry
• Materials science
• Anatomy

Selected publications

• Cardiac matrix-bound Nanovesicles provide insight into mechanisms of clinical heart disease progression to failure

  International Journal of Cardiology · 2024-12-09 · 3 citations

  articleOpen access
  PublisherOA PDFDOI

• Migrasomes, Matrix-bound Nanovesicles, and More: Messengers in the Matrix

  2025-03-28 · 1 citations

  preprintOpen access

  Extracellular vesicles (EVs) and particles (EPs) are diverse micro- and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix-bound or matrix-associated EVs and EPs (MEVPs) has been unclear, largely due to an apparent bias in the field towards EVs found in fluids and a lack of consensus guidelines. Recently, there has been a growing appreciation for several s…

  PublisherOA PDFDOI

• Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

  PROTEOMICS · 2025-10-14 · 1 citations

  articleOpen accessCorresponding

  Extracellular vesicles (EVs) and particles (EPs) are diverse micro- and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix-bound or matrix-associated EVs and EPs (MEVPs) have been unclear, largely due to a lack of consensus guidelines and a relatively miniscule amount of received attention in comparison to EVs found in fluids. Recently, there has been a gr…

  PublisherOA PDFDOI

• Defining characteristics of mesenchymal stem cell-derived matrix-bound nanovesicles compared to conditioned culture medium extracellular vesicles

  bioRxiv (Cold Spring Harbor Laboratory) · 2026-05-08

  articleOpen accessSenior authorCorresponding

  cultured cell sheets, demonstrating remarkable attributes in regenerative medicine. However, differences between MBVs and conditioned culture medium-derived EVs (liquid-EVs) have yet to be characterized, and the field currently lacks specific protein markers that can identify MBVs from other EV subtypes. Here, we isolate MBVs and liquid-EVs from bone marrow mesenchymal stem cell (MSC) sheets and define differences in size, protein, and zeta potential between these EVs. We show that there is a co…

  PublisherOA PDFDOI

Frequent coauthors

• Brendan A.C. Harley

  University of Illinois Urbana-Champaign

  42 shared

• Stephen F. Badylak

  University of Pittsburgh

  25 shared

• George S. Hussey

  University of Pittsburgh

  19 shared

• Xiaoyan Ren

  Chengdu Medical College

  15 shared

• Justine C. Lee

  University of California, Los Angeles

  15 shared

• Qi Zhou

  14 shared

• Aleczandria S. Tiffany

  12 shared

• Madeline C. Cramer

  Pennsylvania State University

  10 shared

Labs

• Dewey LabPI

  Not provided

Education

• B.S.

  University of Maine

  2012

• Ph.D., Materials Science and Engineering

  University of Illinois Urbana-Champaign

Awards & honors

• Annual Innovation Award for Outstanding PhD Thesis
• National Science Foundation Graduate Research Fellow (NSF-GR…
• NIH TL1 Clinical and Translational Science Fellowship

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