Luohua Jiang
· Professor of Epidemiology & BiostatisticsUniversity of California, Irvine · Epidemiology & Biostatistics
Active 2000–2024
About
Professor Luohua Jiang is a faculty member in the Department of Epidemiology and Biostatistics at the Joe C. Wen School of Population & Public Health, University of California, Irvine. She holds a Ph.D. in Biostatistics from UCLA and an M.D. from Peking University Health Science Center. Her primary research interests include multilevel and longitudinal data analysis, latent variable modeling, chronic disease epidemiology and prevention, and health disparities research. Her work focuses on applying and developing statistical models to analyze complex and large-scale data to address public health challenges. She has been involved in translating evidence-based diabetes prevention and management interventions into large-scale public health practice among Native Americans, providing statistical leadership and consulting for federally funded studies aimed at reducing health disparities through community-based chronic disease prevention interventions. Her research areas include secondary data analysis of electronic health records, chronic disease epidemiology, and health care utilization. She has contributed extensively to understanding health disparities, diabetes, dementia, and cardiovascular risks in minority populations, especially American Indian and Alaska Native communities.
Research topics
- Medicine
- Computer Science
- Environmental health
- Sociology
- Internal medicine
- Environmental science
- Geography
- Regional science
- Ophthalmology
- Ecology
- Pediatrics
- Optometry
- Socioeconomics
- Biology
- Demography
- Environmental planning
- Family medicine
Selected publications
A randomized study to compare oral potassium binders in the treatment of acute hyperkalemia
BMC Nephrology · 2023 · 20 citations
- Medicine
- Internal medicine
BACKGROUND: Binders in Emergency Room and hospitalized patients) clinical trial is the first head-to-head evaluation of oral potassium binders (cation-exchange resins) for acute hyperkalemia therapy. METHODS: Emergency room and hospitalized patients with a blood potassium level ≥ 5.5 mEq/L are randomized to one of four study groups: potassium binder drug (sodium polystyrene sulfonate, patiromer, or sodium zirconium cyclosilicate) or nonspecific laxative (polyethylene glycol). Exclusion criteria include recent bowel surgery, ileus, diabetic ketoacidosis, or anticipated dialysis treatment within 4 h of treatment drug. Primary endpoints include change in potassium level at 2 and 4 h after treatment drug. Length of hospital stay, next-morning potassium level, gastrointestinal side effects and palatability will also be analyzed. We are aiming for a final cohort of 80 patients with complete data endpoints (20 per group) for comparative statistics including multivariate adjustment for kidney function, diabetes mellitus, congestive heart failure, metabolic acidosis, renin-angiotensin-aldosterone system inhibitor prescription, and treatment with other agents to lower potassium (insulin, albuterol, loop diuretics). DISCUSSION: The findings from our study will inform decision-making guidelines on the role of oral potassium binders in the treatment of acute hyperkalemia. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04585542 . Registered 14 October 2020.
The Science of The Total Environment · 2021 · 76 citations
- Computer Science
- Sociology
- Geography
Environment International · 2020 · 98 citations
- Environmental health
- Environmental science
- Medicine
BACKGROUND: Recent studies have reported inconsistent associations between maternal residential green space and preterm birth (PTB, born < 37 completed gestational weeks). In addition, windows of susceptibility during pregnancy have not been explored and potential interactions of green space with air pollution exposures during pregnancy are still unclear. OBJECTIVES: To evaluate the relationships between green space and PTB, identify windows of susceptibility, and explore potential interactions between green space and air pollution. METHODS: )] were examined on both additive and multiplicative scales. RESULTS: In total, 3,753,799 eligible births were identified, including 341,123 (9.09%) PTBs, 124,631 (3.32%) MPTBs, and 22,313 (0.59%) VPTBs. A reduced risk of PTB was associated with increases in residential NDVI exposure in 250 m, 500 m, 1000 m, and 2000 m buffers. In the 2000 m buffer, the association was strongest for VPTB [adjusted hazard ratio (HR) per interquartile range increase in NDVI: 0.959, 95% confidence interval (CI): 0.942-0.976)], followed by MPTB (HR = 0.970, 95% CI: 0.962-0.978) and overall PTB (HR = 0.972, 95% CI: 0.966-0.978). For PTB, green space during the 3rd - 5th gestational months had stronger associations than those in the other time periods, especially during the 4th gestational month (NDVI 2000 m: HR = 0.970, 95% CI: 0.965-0.975). We identified consistent positive additive and multiplicative interactions between decreasing green space and higher air pollution. CONCLUSION: This large study found that maternal exposure to residential green space was associated with decreased risk of PTB, MPTB, and VPTB, especially in the second trimester. There is a synergistic effect between low green space and high air pollution levels on PTB, indicating that increasing exposure to green space may be more beneficial for women with higher air pollution exposures during pregnancy.
BMJ Open Diabetes Research & Care · 2020 · 54 citations
- Medicine
- Ophthalmology
- Family medicine
INTRODUCTION: Telemedicine-based diabetic retinopathy screening (DRS) in primary care settings has increased the screening rates of patients with diabetes. However, blindness from vision-threatening diabetic retinopathy (VTDR) is a persistent problem. This study examined the extent of patients' adherence to postscreening recommendations. RESEARCH DESIGN/METHODS: A retrospective record review was conducted in primary care clinics of a large county hospital in the USA. All patients with diabetes detected with VTDR in two time periods, differing in record type used, were included in the study: 2012-2014, paper charts only; 2015-2017, combined paper charts/electronic medical records (EMRs), or EMRs only. Adherence rates for keeping initial ophthalmology appointments, starting recommended treatments, and keeping follow-up appointments were determined. RESULTS: Adequate records were available for 6046 patients; 408 (7%) were detected with VTDR and recommended for referral to ophthalmology. Only 5% completed a first ophthalmology appointment within recommended referral interval, 15% within twice the recommended interval, and 51% within 1 year of DRS. Patients screened in 2015-2017 were more likely to complete a first ophthalmology appointment than those in 2012-2014. Ophthalmic treatment was recommended in half of the patients, of whom 94% initiated treatment. A smaller percentage (41%) adhered completely to post-treatment follow-up. Overall, 28% of referred patients: (1) kept a first ophthalmology appointment; (2) were recommended for treatment; and (3) initiated the treatment. Most patients failing to keep first ophthalmology appointments continued non-ophthalmic medical care at the institution. EMRs provided more complete information than paper charts. CONCLUSIONS: Reducing vision impairment from VTDR requires greater emphasis on timely adherence to ophthalmology referral and follow-up. Prevention of visual loss from VTDR starts with retinopathy screening, but must include patient engagement, adherence monitoring, and streamlining ophthalmic referral and management. Revision of these processes has already been implemented at the study site, incorporating lessons from this investigation.
Recent grants
NIH · $425k · 2019
Frequent coauthors
- 116 shared
Spero M. Manson
University of Colorado Anschutz Medical Campus
- 71 shared
Janette Beals
University of Colorado Anschutz Medical Campus
- 60 shared
Matthew Lee Smith
Texas A&M University
- 49 shared
Angela G. Brega
University of Colorado Anschutz Medical Campus
- 42 shared
Marcia G. Ory
Texas A&M University
- 41 shared
Joan O’Connell
Native Health
- 34 shared
María M. Corrada
University of California, Irvine
- 30 shared
SangNam Ahn
Texas A&M Health Science Center
Education
- 1996
Ph.D., Environmental Health Sciences
University of California, Los Angeles
- 1993
M.S., Environmental Health Sciences
University of California, Los Angeles
- 1991
B.S., Environmental Health Sciences
University of California, Los Angeles
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