Linfeng Zhang
Ohio State University · Mathematics
Active 1994–2024
Research topics
- Chemistry
- Cell biology
- Biology
- Biochemistry
Selected publications
The Journal of Experimental Medicine · 2020 · 193 citations
- Cell biology
- Chemistry
- Biology
Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS via a caspase-11/NLRP3-dependent manner. Further studies show that NLRP3 undergoes both K63- and K48-linked polyubiquitination. Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. We also identify RNF125 as an additional E3 ubiquitin ligase that initiates K63-linked ubiquitination of the NLRP3 LRR domain. Therefore, NLRP3 is sequentially ubiquitinated by K63- and K48-linked ubiquitination, thus keeping the NLRP3 inflammasomes in check and restraining endotoxemia.
Frequent coauthors
- 95 shared
Yuquan Xu
Biotechnology Research Institute
- 82 shared
Chen Wang
Biotechnology Research Institute
- 60 shared
Qun Yue
Chinese Academy of Agricultural Sciences
- 48 shared
István Molnár
Southwest Center for Educational Excellence
- 31 shared
Linan Xie
Northeast Forestry University
- 30 shared
Xiaohong Zheng
Nanjing Forestry University
- 28 shared
Min Lin
South China Agricultural University
- 24 shared
Baoqing Dun
Institute of Crop Sciences
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