Linda Bockenstedt
· Harold W. Jockers Professor of MedicineYale University · Rheumatology
Active 1980–2026
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About
Dr. Linda Bockenstedt is the Harold W. Jockers Professor of Medicine in the Section of Rheumatology at Yale School of Medicine and serves as Deputy Dean for Faculty Affairs. She received her undergraduate degree in chemistry and physics from Harvard College and earned her medical degree from Ohio State University School of Medicine. After completing residency training in medicine and serving as Chief Resident at Yale, she pursued rheumatology clinical and research fellowship training at the University of California, San Francisco. She has been a faculty member at Yale since 1989, where she directs a research program focused on understanding the pathogenesis of Lyme disease, an infection-related rheumatic disease. Her research has been supported by the National Institutes of Health since 1990, and she is recognized internationally for her studies of the host immune response to spirochetal infection. Dr. Bockenstedt is a Master of the American College of Rheumatology, a member of the Kunkel Society and the Interurban Clinical Club, and has served on various NIH and professional organization committees. Her research primarily explores the immune response to Lyme disease, including host-pathogen interactions, immune evasion mechanisms of Borrelia burgdorferi, and the development of improved diagnostic methods for Lyme disease. She is also actively involved in clinical practice and medical education.
Research topics
- Internal medicine
- Family medicine
- Medicine
- Immunology
- Pathology
- Psychiatry
- Intensive care medicine
Selected publications
Clinical Infectious Diseases · 2020 · 339 citations
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of America (IDSA), the American Academy of Neurology (AAN), and the American College of Rheumatology (ACR). The scope of this guideline includes prevention of Lyme disease, and the diagnosis and treatment of Lyme disease presenting as erythema migrans, Lyme disease complicated by neurologic, cardiac, a…
Arthritis Care & Research · 2020 · 134 citations
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of North American (IDSA), the American Academy of Neurology (AAN), and the American College of Rheumatology (ACR). The scope of this guideline includes prevention of Lyme disease, and the diagnosis and treatment of Lyme disease presenting as erythema migrans, Lyme disease complicated by neurologic, car…
Arthritis & Rheumatology · 2020 · 71 citations
This evidence-based clinical practice guideline for the prevention, diagnosis, and treatment of Lyme disease was developed by a multidisciplinary panel representing the Infectious Diseases Society of North American (IDSA), the American Academy of Neurology (AAN), and the American College of Rheumatology (ACR). The scope of this guideline includes prevention of Lyme disease, and the diagnosis and treatment of Lyme disease presenting as erythema migrans, Lyme disease complicated by neurologic, car…
Immune Response to <i>Borrelia</i>: Lessons from Lyme Disease Spirochetes
Current Issues in Molecular Biology · 2020-12-08 · 40 citations
reviewOpen access1st authorCorrespondingThe mammalian host responds to infection with Borrelia spirochetes through a highly orchestrated immune defense involving innate and adaptive effector functions aimed toward limiting pathogen burdens, minimizing tissue injury, and preventing subsequent reinfection. The evolutionary adaptation of Borrelia spirochetes to their reservoir mammalian hosts may allow for its persistence despite this immune defense. This review summarizes our current understanding of the host immune response to B. burgd…
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
JCI Insight · 2021-06-01 · 38 citations
articleOpen accessSenior authorCorrespondingThe skin lesion erythema migrans (EM) is an initial sign of the Ixodes tick-transmitted Borreliella spirochetal infection known as Lyme disease. T cells and innate immune cells have previously been shown to predominate the EM lesion and promote the reaction. Despite the established importance of B cells and antibodies in preventing infection, the role of B cells in the skin immune response to Borreliella is unknown. Here, we used single-cell RNA-Seq in conjunction with B cell receptor (BCR) sequ…
Recent grants
NIH · $2.1M · 2010
NIH · $578k · 2002
NIH · $1.3M · 2000
Frequent coauthors
- 55 shared
Allen C. Steere
Massachusetts General Hospital
- 49 shared
Peter J. Krause
Yale University
- 43 shared
Gary P. Wormser
New York Medical College
- 43 shared
John Halperin
- 42 shared
Yngve Falck‐Ytter
Case Western Reserve University
- 42 shared
Franc Strle
- 42 shared
Paul G. Auwaerter
Johns Hopkins Medicine
- 41 shared
Lise E. Nigrovic
Harvard University
Awards & honors
- Master of the American College of Rheumatology
- Elected member of the Kunkel Society
- Elected member of the Interurban Clinical Club
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