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Richard Bucala

· Waldemar Von Zedtwitz Professor of Medicine (Rheumatology) and Professor of Pathology and of Epidemiology (Microbial Diseases); Chief, Rheumatology, Allergy, & Immunology; Affiliated Faculty, Yale Institute for Global Health; Rheumatologist in Chief, Rheumatology, YNHH

Yale University · Rheumatology

Active 1982–2025

h-index114
Citations48.9k
Papers58888 last 5y
Funding$123.6M4 active

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

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About

The provided page text does not contain a specific professional biography of Professor Richard Bucala. It primarily describes the research activities, strategic plans, and general achievements of Yale School of Medicine and its faculty, without detailed personal or research focus information about Professor Bucala.

Research topics

  • Medicine
  • Immunology
  • Biology
  • Internal medicine
  • Pathology
  • Cancer research
  • Cell biology
  • Biochemistry
  • Virology

Selected publications

  • Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019

    CHEST Journal · 2020 · 214 citations

    DOI

  • Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer

    Cell Death and Disease · 2021 · 109 citations

    Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but its expression is increased in some cancers via stabilization with HSP90-associated chaperones. Here, we show that MIF stabilization is tumor-specific in an acute colitis-associated colorectal cancer (CRC) mouse model, leading to tumor-specific functions and selective therapeutic vulnerabilities. Therefore, we demonstrate that a Mif deletion reduced CRC tumor growth. Further, we define a dual role for M…

    DOI

  • CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing

    Cellular and Molecular Gastroenterology and Hepatology · 2020 · 83 citations

    BACKGROUND & AIMS: The inflammatory response to intestinal damage promotes healing through mechanisms that are incompletely understood. Gene expression of cluster of differentiation 74 (CD74), the receptor for cytokine macrophage migration inhibitory factor, is increased in patients with inflammatory bowel disease (IBD), however, the role of CD74 signaling in intestinal inflammation remains poorly understood. The aim of this study was to determine the functional role of CD74 signaling in intesti…

    DOI

  • MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model

    Journal of Clinical Investigation · 2021 · 63 citations

    Senior authorCorresponding

    Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrometautomerase (D-DT/MIF-2), prompted closer investigation of MIF-dependent responses. We subjected Mif(-…

    DOI

  • MIF contribution to progressive brain diseases

    Journal of Neuroinflammation · 2024-01-04 · 27 citations

    articleOpen access

    Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the base of many progressive brain malfunctions is a process of unresolved, chronic inflammation. Macrophage migration inhibitory factor, MIF, is an inflammatory mediator that recently gained interest of neuro-researchers due to its varied effects on the CNS such…

    PublisherOA PDFDOI

Recent grants

Frequent coauthors

  • Lin Leng

    Yale University

    387 shared

  • Andreas Meinhardt

    Hudson Institute of Medical Research

    124 shared

  • Wise Young

    Rutgers, The State University of New Jersey

    110 shared

  • Iman Tadmori

    110 shared

  • Changshun Shao

    Changchun University of Science and Technology

    110 shared

  • Kai Cao

    University Radiology

    110 shared

  • Liang Li

    Guangdong Provincial People's Hospital

    110 shared

  • Jianqing Fan

    110 shared

Education

  • M.D., Medicine

    Yale University School of Medicine

    1990

  • Ph.D., Immunology

    Yale University School of Medicine

    1985

Awards & honors

  • American Society for Clinical Investigation
  • Association of American Physicians

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