Liara Gonzalez

About

Sarah Ho is the CVM Director of Student Engagement at the College of Veterinary Medicine at NC State University. Her role involves fostering student success and engagement within the college community. The page highlights her contact information and her position as a key figure in student development and involvement, but does not provide specific details about her research focus, academic background, or key contributions in the field of veterinary medicine.

Research topics

• Biology
• Genetics
• Cell biology
• Medicine
• Sociology
• Immunology
• Internal medicine
• Molecular biology
• Cancer research
• Bioinformatics

Selected publications

• Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection

  Proceedings of the National Academy of Sciences · 2022 · 36 citations

  Zoonotic transmission of coronaviruses poses an ongoing threat to human populations. Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV) have caused severe economic losses in the pig industry and have the potential to cause human outbreaks. Currently, there are no vaccines or specific antivirals against SADS-CoV, and our limited understanding of SADS-CoV host entry factors could hinder prompt responses to a potential human outbreak. Using a genomewide CRISPR knockout screen…

  DOI

• HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia

  AJP Gastrointestinal and Liver Physiology · 2021 · 29 citations

  Senior authorCorresponding

  controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, we use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets.

  PublisherOA PDFDOI

• A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

  The FASEB Journal · 2023 · 18 citations

  Senior authorCorresponding

  ISCs are reproducibly isolated in LGR5-H2B-GFP pigs and used to model CRC in an organoid platform. The known anatomical and physiologic similarities between pig and human, and those shown by crypt-base FISH, underscore the significance of this novel LGR5-H2B-GFP pig to translational ISC research.

  PublisherOA PDFDOI

• Biomarkers of Intestinal Injury in Colic

  Animals · 2023-01-07 · 18 citations

  reviewOpen accessSenior authorCorresponding

  Biomarkers are typically proteins, enzymes, or other molecular changes that are elevated or decreased in body fluids during the course of inflammation or disease. Biomarkers pose an extremely attractive tool for establishing diagnoses and prognoses of equine gastrointestinal colic, one of the most prevalent causes of morbidity and mortality in horses. This topic has received increasing attention because early diagnosis of some forms of severe colic, such as intestinal ischemia, would create oppo…

  PublisherOA PDFDOI

• Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability

  American Journal of Transplantation · 2023-11-01 · 14 citations

  articleOpen accessSenior authorCorresponding

  Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury (IRI). Severe IRI impairs epithelial barrier function, including loss of intestinal stem cells (ISC), critical to epithelial regeneration. Normothermic machine perfusion (NMP) preservation of kidney and liver allografts minimizes CS-associated…

  PublisherOA PDFDOI

Recent grants

• Intestinal stem cell responses to ischemic injury in a large animal model

  NIH · $608k · 2015–2021

Frequent coauthors

• Anthony T. Blikslager

  North Carolina State University

  34 shared

• John M. Freund

  North Carolina State University

  22 shared

• Amy Stieler Stewart

  North Carolina State University

  20 shared

• Cecilia R. Schaaf

  North Carolina State University

  17 shared

• Katherine S. Garman

  Duke University

  11 shared

• Scott T. Magness

  North Carolina State University

  11 shared

• Amanda L. Ziegler

  North Carolina State University

  10 shared

• Brittany Veerasammy

  North Carolina State University

  9 shared

Awards & honors

• Comparative Medicine and Translational Research Training Pro…

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