Liang Fang

About

Liang Fang is a faculty member at the Cornell Duffield Engineering, specifically associated with the Meinig School of Biomedical Engineering. He holds the position of Postdoctoral Associate and is part of the Jiang Lab. His work is conducted within a highly collaborative and dynamic intellectual community known for excellence in educating students, pursuing groundbreaking research, and advancing technological innovations that impact people, communities, and the world. The community emphasizes a commitment to education, research, and technological development, contributing to the broader mission of Cornell Engineering.

Research topics

• Biology
• Cell biology
• Medicine
• Immunology
• Chemistry

Selected publications

• AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

  Science · 2019-02-01 · 125 citations

  articleOpen accessSenior authorCorresponding

  Hypercholesterolemia, the driving force of atherosclerosis, accelerates the expansion and mobilization of hematopoietic stem and progenitor cells (HSPCs). The molecular determinants connecting hypercholesterolemia with hematopoiesis are unclear. Here, we report that a somite-derived prohematopoietic cue, AIBP, orchestrates HSPC emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. Mechanistically, AIBP-mediated cholesterol efflux activat…

  PublisherOA PDFDOI

• A visual–omics foundation model to bridge histopathology with spatial transcriptomics

  Nature Methods · 2025-05-29 · 60 citations

  articleOpen access

  Artificial intelligence has revolutionized computational biology. Recent developments in omics technologies, including single-cell RNA sequencing and spatial transcriptomics, provide detailed genomic data alongside tissue histology. However, current computational models focus on either omics or image analysis, lacking their integration. To address this, we developed OmiCLIP, a visual-omics foundation model linking hematoxylin and eosin images and transcriptomics using tissue patches from Visium…

  PublisherOA PDFDOI

• AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation

  JCI Insight · 2018-08-22 · 55 citations

  articleOpen access

  Acute respiratory distress syndrome (ARDS) is characterized by an excessive pulmonary inflammatory response. Removal of excess cholesterol from the plasma membrane of inflammatory cells helps reduce their activation. The secreted apolipoprotein A-I binding protein (AIBP) has been shown to augment cholesterol efflux from endothelial cells to the plasma lipoprotein HDL. Here, we find that AIBP was expressed in inflammatory cells in the human lung and was secreted into the bronchoalveolar space in…

  PublisherOA PDFDOI

• Regulation of lipid rafts, angiogenesis and inflammation by AIBP

  Current Opinion in Lipidology · 2019-04-13 · 52 citations

  reviewOpen access1st authorCorresponding

  PURPOSE OF REVIEW: Recent studies demonstrate an important role of the secreted apolipoprotein A-I binding protein (AIBP) in regulation of cholesterol efflux and lipid rafts. The article discusses these findings in the context of angiogenesis and inflammation. RECENT FINDINGS: Lipid rafts are cholesterol-rich and sphingomyelin-rich membrane domains in which many receptor complexes assemble upon activation. AIBP mediates selective cholesterol efflux, in part via binding to toll-like receptor-4 (T…

  PublisherOA PDFDOI

• TBX20 Regulates Angiogenesis Through the Prokineticin 2–Prokineticin Receptor 1 Pathway

  Circulation · 2018-03-15 · 49 citations

  articleOpen accessSenior author

  BACKGROUND: Angiogenesis is integral for embryogenesis, and targeting angiogenesis improves the outcome of many pathological conditions in patients. TBX20 is a crucial transcription factor for embryonic development, and its deficiency is associated with congenital heart disease. However, the role of TBX20 in angiogenesis has not been described. METHODS: Loss- and gain-of-function approaches were used to explore the role of TBX20 in angiogenesis both in vitro and in vivo. Angiogenesis gene array…

  PublisherOA PDFDOI

Recent grants

• AIBP Mediates a Novel Interplay between Cholesterol Metabolism and Lymphangiogenesis

  NIH · $2.7M · 2016–2022

• NIH Grant R00HL114734

  NIH · $738k · 2018

• NIH Grant K99HL114734

  NIH · $238k · 2014

Frequent coauthors

• Yury I. Miller

  University of California, San Diego

  105 shared

• McKenna J. Geary

  University of California, San Diego

  64 shared

• Po‐Hsun Huang

  Taipei Veterans General Hospital

  64 shared

• Ting-Yang Lin

  Keelung Chang Gung Memorial Hospital

  64 shared

• Jaw‐Wen Chen

  Taipei Veterans General Hospital

  64 shared

• Liang Wen

  South China Normal University

  64 shared

• John Y.‐J. Shyy

  University of California, San Diego

  64 shared

• David A. Johnson

  64 shared

Labs

• Jiang LabPI

Education

• Postdoc/Assist Proj Sci, Medicine

  University of California San Diego

  2014

• Ph.D, Institute of Biochmestry and Cell Biology

  Shanghai Institutes for Biological Sciences

  2007

• B.S, Biology

  Anhui Normal University

  2000

Awards & honors

• SPROUT Awards
• EPICC Awards
• Research, Teaching, and Advising Awards
• Distinguished Alumni Award

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