Lauren M Massimo

About

Lauren M Massimo is an Assistant Professor of Neurology at the University of Pennsylvania's Perelman School of Medicine. She is affiliated with the Neuroscience graduate group and is part of the faculty within the Biomedical Graduate Studies. Her contact email is lmassimo@nursing.upenn.edu. The available information does not include specific details about her research focus, background, or key contributions.

Research topics

• Medicine
• Neuroscience
• Biology
• Chemistry
• Genetics
• Psychology
• Pathology
• Physical medicine and rehabilitation
• Molecular biology
• Cell biology

Selected publications

• Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

  Science · 2020 · 141 citations

  is an autosomal-dominant genetic mutation associated with neurofibrillary degeneration in part owing to reduced tau disaggregation, raising the possibility that VCP may represent a therapeutic target for the treatment of AD.

  DOI

• Tau immunotherapy is associated with glial responses in FTLD-tau

  Acta Neuropathologica · 2021-05-05 · 43 citations

  articleOpen access

  Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologic subtypes of frontotemporal lobar degeneration with tau inclusions (FTLD-tau), primary tauopathies in which intracellular tau aggregation contributes to neurodegeneration. Gosuranemab (BIIB092) is a humanized monoclonal antibody that binds to N-terminal tau. While Gosuranemab passive immunotherapy trials for PSP failed to demonstrate clinical benefit, Gosuranemab reduced N-terminal tau in the cerebrospina…

  PublisherOA PDFDOI

• Automated analysis of lexical features in frontotemporal degeneration

  Cortex · 2021-02-06 · 42 citations

  articleOpen access
  PublisherOA PDFDOI

• Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology

  JAMA Neurology · 2025-09-08 · 12 citations

  articleOpen access

  Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy. Objective: To examine associations between PM2.5 exposure, dementia severity, and dementia-associated neuropathologic change. Design, Setting, and Participants: This cohort study used data associated with autopsy cases collected from 1999 to 2022 at the Center for Neurodegenerative Dis…

  PublisherOA PDFDOI

• Cognitive reserve in ALS: the role of occupational skills and requirements

  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · 2024 · 6 citations

  OBJECTIVE: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative condition featuring variable degrees of motor and cognitive impairment. We assessed the impact of specific, empirically derived occupational skills and requirements on cognitive and motor functioning in ALS. METHODS: Individuals with ALS (n = 150) were recruited from the University of Pennsylvania's Comprehensive ALS Clinic. The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) measured cognition, and the Penn…

  PublisherOA PDFDOI

Recent grants

• Cognitive and Neural Moderators of Longitudinal Decline in Frontotemporal Degeneration

  NIH · $192k · 2016–2018

• Cognitive and Neural Moderators of Longitudinal Decline in Frontotemporal Degeneration

  NIH · $747k · 2016–2022

• The Neural Basis of Apathy in Frontotemporal Degeneration: A Longitudinal Study

  NIH · $144k · 2014–2017

Frequent coauthors

• Murray Grossman

  78 shared

• Corey T. McMillan

  University of Pennsylvania

  68 shared

• David J. Irwin

  University of Pennsylvania

  49 shared

• Sharon X. Xie

  32 shared

• Katya Rascovsky

  University of Pennsylvania

  28 shared

• John Q. Trojanowski

  University of Pennsylvania

  24 shared

• Anjan Chatterjee

  Insmed (United States)

  22 shared

• Ann Kolanowski

  20 shared

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