Larry J Suva

Similarities Between Disuse and Age-Induced Bone Loss

Journal of Bone and Mineral Research · 2020 · 51 citations

Disuse and aging are known risk factors associated with low bone mass and quality deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence implicate a large number of shared skeletal manifestations between disuse and aging scenarios. This review provides a detailed overview of current preclinical models of musculoskeletal disuse and the clinical scenarios they seek to recapitulate. We also explore and summarize the major similarities between bone loss after extr…

Bisphosphonates in veterinary medicine: The new horizon for use

Bone · 2020 · 41 citations

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations

Bone · 2020 · 27 citations

Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome

Advanced Materials · 2023-06-06 · 24 citations

Abstract Hydrogen sulfide (H 2 S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H 2 S is elevated and associated with degraded mitochondrial function. Therefore, removing H 2 S from the body as a stable oxide could be an approach to reducing the deleterious effects of H 2 S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H 2 S) to polysulfides (HS 2+n − ) and thiosulfate (S…

Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine

Development · 2022 · 20 citations

Amputation injuries in mammals are typically non-regenerative; however, joint regeneration is stimulated by BMP9 treatment, indicating the presence of latent articular chondrocyte progenitor cells. BMP9 induces a battery of chondrogenic genes in vivo, and a similar response is observed in cultures of amputation wound cells. Extended cultures of BMP9-treated cells results in differentiation of hyaline cartilage, and single cell RNAseq analysis identified wound fibroblasts as BMP9 responsive. This…