About

Kyle Jeffrie Gaulton is an Associate Professor at the University of Pennsylvania, with a background in BAS Computer Science from UPenn and a PhD in Genetics and Molecular Biology from UNC Chapel Hill. His research focuses on genetics, molecular biology, and bioinformatics, as evidenced by his role in the Gaulton Lab where he leads efforts in computational biology and biomedical sciences. The lab includes a diverse team of researchers and students working on various aspects of biomedical research, bioinformatics, and tissue engineering, indicating his active engagement in advancing understanding in these fields.

Research topics

• Biology
• Genetics
• Computational biology
• Medicine
• Evolutionary biology
• Pathology
• Demography
• Virology
• Anatomy
• Cell biology
• Immunology
• Bioinformatics

Selected publications

• Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

  Nature Cell Biology · 2023 · 170 citations

  • Computational biology
  • Cell biology
  • Biology
  PublisherOA PDFDOI

• Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

  Nature Genetics · 2022 · 724 citations

  • Biology
  • Genetics
  • Evolutionary biology
  DOI

• Cardiac cell type–specific gene regulatory programs and disease risk association

  Science Advances · 2021 · 140 citations

  • Computational biology
  • Biology
  • Medicine

  expression and action potential repolarization. Overall, this atlas of human cardiac cCREs provides the foundation for illuminating cell type-specific gene regulation in human hearts during health and disease.

  DOI

• Systematic analysis of binding of transcription factors to noncoding variants

  Nature · 2021 · 174 citations

  • Biology
  • Computational biology
  • Genetics
  DOI

• Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

  Nature Medicine · 2021 · 372 citations

  • Biology
  • Immunology
  • Virology

  cells in nasal, lung and gut tissues included genes that may mediate viral entry, key immune functions and epithelial-macrophage cross-talk, such as genes involved in the interleukin-6, interleukin-1, tumor necrosis factor and complement pathways. Cell-type-specific expression patterns may contribute to the pathogenesis of COVID-19, and our work highlights putative molecular pathways for therapeutic intervention.

  PublisherOA PDFDOI

• De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

  Proceedings of the National Academy of Sciences · 2020 · 110 citations

  • Genetics
  • Biology
  • Evolutionary biology

  ), which suggest that variation in DNM rate is significantly shaped by nonadditive genetic effects and the environment.

  DOI

Recent grants

• Diabetes risk variants affecting transcription factor-regulated cellular networks

  NIH · $1.9M · 2018–2023

• Single cell analysis of the human pancreas in type 1 diabetes

  NIH · $3.1M · 2018–2022

• Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic islets

  NIH · $4.4M · 2019–2023

Frequent coauthors

• Mark I. McCarthy

  University of Oxford

  294 shared

• Andrew P. Morris

  Versus Arthritis

  129 shared

• David Altshuler

  117 shared

• Inga Prokopenko

  University of Surrey

  113 shared

• Cecilia M. Lindgren

  106 shared

• José C. Florez

  Harvard University

  106 shared

• Anna L. Gloyn

  Stanford University

  104 shared

• Anubha Mahajan

  103 shared

Similar researchers at University of California, San Diego

• Ronald M. Evansh-300
• Rob Knighth-297
• Michael (Geoff) Rosenfeldh-224
• Don W. Clevelandh-213
• Anders M Daleh-209