Kwangsun Ray Yoo

Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank

The Lancet Digital Health · 2023-04-13 · 104 citations

BACKGROUND: Physical frailty is a state of increased vulnerability to stressors and is associated with serious health issues. However, how frailty affects and is affected by numerous other factors, including mental health and brain structure, remains underexplored. We aimed to investigate the mutual effects of frailty and health using large, multidimensional data. METHODS: For this population-based study, we used data from the UK Biobank to examine the pattern and direction of association betwee…

Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice

Free Radical Biology and Medicine · 2022-01-06 · 75 citations

Differences in the functional brain architecture of sustained attention and working memory in youth and adults

PLoS Biology · 2022-12-21 · 41 citations

Sustained attention (SA) and working memory (WM) are critical processes, but the brain networks supporting these abilities in development are unknown. We characterized the functional brain architecture of SA and WM in 9- to 11-year-old children and adults. First, we found that adult network predictors of SA generalized to predict individual differences and fluctuations in SA in youth. A WM model predicted WM performance both across and within children-and captured individual differences in later…

Edge-Based General Linear Models Capture Moment-to-Moment Fluctuations in Attention

Journal of Neuroscience · 2024-02-05 · 11 citations

Although we must prioritize the processing of task-relevant information to navigate life, our ability to do so fluctuates across time. Previous work has identified fMRI functional connectivity (FC) networks that predict an individual's ability to sustain attention and vary with attentional state from 1 min to the next. However, traditional dynamic FC approaches typically lack the temporal precision to capture moment-to-moment network fluctuations. Recently, researchers have "unfurled" traditiona…

High performers demonstrate greater neural synchrony than low performers across behavioral domains

Imaging Neuroscience · 2024-03-21 · 5 citations

Heterogeneity in brain activity can give rise to heterogeneity in behavior, which in turn comprises our distinctive characteristics as individuals. Studying the path from brain to behavior, however, often requires making assumptions about how similarity in behavior scales with similarity in brain activity. Here, we expand upon recent work (Finn et al., 2020) which proposes a theoretical framework for testing the validity of such assumptions. Using intersubject representational similarity analysi…