Keyue Shen

About

Keyue Shen is an Associate Professor of Biomedical Engineering and a member of the USC Norris Comprehensive Cancer Center as well as USC Stem Cell. He serves as the Principal Investigator at the Laboratory for Integrative Biosystems Engineering. His academic background includes a postdoctoral fellowship at Harvard Medical School and Massachusetts General Hospital, a Ph.D. in Biomedical Engineering from Columbia University, an M.S. in Biophysics, and a B.E. in Mechanical Engineering, both from Tsinghua University. The information provided focuses on his academic credentials and leadership role within the laboratory, but does not detail specific research interests or contributions.

Research topics

• Biochemistry
• Biology
• Medicine
• Cancer research
• Internal medicine
• Chemistry
• Cell biology
• Endocrinology
• Immunology
• Genetics

Selected publications

• Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells

  WIREs Mechanisms of Disease · 2023 · 109 citations

  Senior authorCorresponding

  . This article is categorized under: Cancer > Environmental Factors Cancer > Biomedical Engineering Cancer > Molecular and Cellular Physiology.

  PublisherOA PDFDOI

• Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination

  Cell Reports · 2021 · 55 citations

  Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum. Although abnormal GABAergic receptor activation has been described in MB, studies have not yet elucidated the contribution of receptor-independent GABA metabolism to MB pathogenesis. We find primary MB tumors globally display decreased expression of GABA transaminase (ABAT), the protein responsible for GABA metabolism, compared with normal cerebellum. However, less aggressive WNT and SHH subtypes express higher…

  DOI

• CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation

  Journal of Controlled Release · 2020 · 40 citations

  DOI

• Non-invasive Optical Biomarkers Distinguish and Track the Metabolic Status of Single Hematopoietic Stem Cells

  iScience · 2020 · 12 citations

  Senior authorCorresponding

  with enhanced glycolysis under HSC stemness-maintaining conditions during HSC culture. Our work thus provides a new paradigm to identify and track the metabolism of single HSCs non-invasively and in real time.

  PublisherDOI

• Label-free metabolic optical biomarkers track stem cell fate transition in real time

  Science Advances · 2024-05-08 · 9 citations

  articleOpen accessSenior authorCorresponding

  Tracking stem cell fate transition is crucial for understanding their development and optimizing biomanufacturing. Destructive single-cell methods provide a pseudotemporal landscape of stem cell differentiation but cannot monitor stem cell fate in real time. We established a metabolic optical metric using label-free fluorescence lifetime imaging microscopy (FLIM), feature extraction and machine learning-assisted analysis, for real-time cell fate tracking. From a library of 205 metabolic optical…

  PublisherOA PDFDOI

Recent grants

• Artificial Stromal Cell for Hematopoietic Stem Cell Expansion

  NIH · $637k · 2017–2021

• (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis

  NIH · $2.2M · 2019–2025

Frequent coauthors

• Dennis A. Wigle

  144 shared

• Stephen D. Cassivi

  139 shared

• Mark S. Allen

  135 shared

• Francis C. Nichols

  Mayo Clinic in Arizona

  124 shared

• Claude Deschamps

  95 shared

• Martin L. Yarmush

  Shriners Hospitals for Children - Boston

  90 shared

• Shanda H. Blackmon

  Mayo Clinic in Arizona

  48 shared

• Jessica S. Elman

  Tufts University

  46 shared

Labs

• Laboratory for Integrative Biosystems EngineeringPI

  Associate Professor of Biomedical Engineering Member of USC Norris Comprehensive Cancer Center USC Stem Cell Principle Investigator

Education

• Ph.D., Biomedical Engineering

  University of Southern California

  2004

• M.S., Biomedical Engineering

  University of Southern California

  2001

• B.S., Biomedical Engineering

  University of Southern California

  1999

Awards & honors

• MGH Fund for Medical Discovery Award
• Marni Levine Memorial Research Development Award from STOP C…
• Trailblazer Award from National Institute of Biomedical Imag…
• Rose Hills Research Fellowship from USC

Similar researchers at University of Southern California

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• Qifa Zhouh-64
• Ted William Bergerh-58