Karl Deisseroth
· D. H. Chen Professor, Professor of Bioengineering and of Psychiatry and Behavioral SciencesStanford University · Bioengineering
Active 1990–2026
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About
Karl Deisseroth is the D. H. Chen Professor, Professor of Bioengineering, and of Psychiatry and Behavioral Sciences at Stanford University. His research focuses on bioengineering and behavioral sciences, contributing to the understanding and development of innovative techniques in these fields. As a prominent figure in his discipline, he has made significant contributions to the intersection of bioengineering and mental health, advancing both scientific knowledge and practical applications in these areas.
Research topics
- Neuroscience
- Biology
- Computer Science
- Cell biology
- Artificial Intelligence
- Chemistry
- Psychology
- Medicine
- Biochemistry
- Materials science
Selected publications
Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics
Science · 2022 · 574 citations
Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless and biocompatible integration with the human body. A remaining challenge is to combine high mechanical robustness with good electrical conduction, especially when patterned at small feature sizes. We develop a molecular engineering strategy based on a topological supramolecular network, which allows for the decoupling of competing effects from mult…
Maturation and circuit integration of transplanted human cortical organoids
Nature · 2022 · 463 citations
. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrate into sensory and motivation-related circuits. MRI reveals post-transplantation organoid growth across multiple stem cell lines and animals, whereas single-nucleus pro…
Deep posteromedial cortical rhythm in dissociation
Nature · 2020 · 284 citations
Senior authorCorrespondingGenetically targeted chemical assembly of functional materials in living cells, tissues, and animals
Science · 2020 · 199 citations
Senior authorCorrespondingThe structural and functional complexity of multicellular biological systems, such as the brain, are beyond the reach of human design or assembly capabilities. Cells in living organisms may be recruited to construct synthetic materials or structures if treated as anatomically defined compartments for specific chemistry, harnessing biology for the assembly of complex functional structures. By integrating engineered-enzyme targeting and polymer chemistry, we genetically instructed specific living…
Neuron · 2020 · 179 citations
Senior authorCorresponding
Recent grants
Single-cell causality in origination, propagation, and resolution of drug-altered brain states
NIH · $45.2M · 2017–2028
NIH · $2.6M · 2012
Channel structure-based tools for precise interrogation of circuitry and behavior
NIH · $7.3M · 2018–2023
Frequent coauthors
- 272 shared
Charu Ramakrishnan
Stanford University
- 136 shared
Lief E. Fenno
The University of Texas at Austin
- 81 shared
Thomas J. Davidson
Howard Hughes Medical Institute
- 75 shared
Kay M. Tye
University of California, San Diego
- 71 shared
Clay Reid
- 67 shared
Talia N. Lerner
Research Network (United States)
- 66 shared
M. L. Roukes
California Institute of Technology
- 66 shared
Lisa A. Gunaydin
University of California, San Francisco
Labs
1-2 sentence research focus
Education
- 1995
B.S., Electrical Engineering and Computer Science
Massachusetts Institute of Technology (MIT)
- 1997
M.S., Bioengineering
Stanford University
- 2000
Ph.D., Bioengineering
Stanford University
Awards & honors
- Investigator of the Howard Hughes Medical Institute
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