About

Joshua Pierce is the JP Howard J. Schaeffer Distinguished Professor of Chemistry and a University Faculty Scholar at NC State University. His research employs synthetic chemistry to address problems in chemical biology and drug discovery. He focuses on developing novel reactions to synthesize complex natural products and applying targeted modifications to gain insights into their biological mechanisms of action. Ultimately, his work aims to uncover new drug lead compounds for further development, contributing to advancements in medicinal chemistry and bioorganic chemistry.

Research topics

• Medicine
• Nuclear physics
• Chemistry
• Condensed matter physics
• Physics
• Optics
• Pathology
• Dentistry
• Materials science
• Biology
• Surgery

Selected publications

• Cherubism: A Case Report

  The UCLA Radiological Science Proceedings · 2023

  • Medicine
  • Pathology
  • Dentistry

  Cherubism is a rare genetic disorder resulting in the replacement of the mandible and sometimes the maxilla with expansile cystic lesions. The disorder usually presents in childhood, with eventual quiescence in early adulthood. We report a case of cherubism involving both the mandible and the maxilla and complicated by mass effect on the nasal cavity and the left orbit. Pathologic features, clinical considerations, and treatment of cherubism are discussed.

  DOI

• Nasal Reconstruction after Mohs Cancer Resection: Lessons Learned from 2553 Consecutive Cases

  Plastic & Reconstructive Surgery · 2021 · 33 citations

  • Medicine
  • Surgery

  BACKGROUND: Nasal defects following Mohs resection are a reconstructive challenge, demanding aesthetic and functional considerations. Many reconstructive modalities are available, each with varying utility and efficacy. The goal of this study was to provide an algorithmic approach to nasal reconstruction and illustrate lessons learned from decades of reconstructing Mohs defects. METHODS: A retrospective review was conducted of consecutive patients who underwent nasal reconstruction after Mohs excision from 2003 to 2019 performed by the senior author (J.F.T.). Data were collected and analyzed regarding patient and clinical demographics, defect characteristics, reconstructive modality used, revisions, and complications. RESULTS: A total of 2553 cases were identified, among which 1550 (1375 patients) were analyzed. Defects most commonly affected the nasal ala (48.1 percent); 74.8 percent were skin-only. Full-thickness skin-grafts were the most common reconstructive method (36.2 percent); 24.4 percent of patients underwent forehead flaps and 17.0 percent underwent nasolabial flaps. The overall complication rate was 11.6 percent (n = 181), with poor wound healing being most common. Age older than 75 years, defects larger than 2 cm2, and active smoking were associated with increased complication rates. CONCLUSIONS: Nasal reconstruction can be divided based on anatomical location, and an algorithmic approach facilitates excellent results. Although local flaps may be suitable for some patients, they are not always the most aesthetic option. The versatility and low risk-to-benefit profile of the forehead flap make it a suitable option for elderly patients. Although reconstruction is still safe to be performed without discontinuation of anticoagulation, older age, smoking, and large defect size are predictors of complications. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.

  DOI

• Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals

  Methods in enzymology on CD-ROM/Methods in enzymology · 2020 · 10 citations

  1st authorCorresponding
  • Optics
  • Physics
  • Materials science
  DOI

Frequent coauthors

• Yelena Prok

  6 shared

• Donald G. Crabb

  McCormick (United States)

  6 shared

• Ivan Bedlinskiy

  5 shared

• C. E. Hyde-Wright

  5 shared

• H. O. Funsten

  New Mexico Consortium

  4 shared

• G. Ricco

  University of Warwick

  4 shared

• C. Butuceanu

  University of Regina

  4 shared

• J. Kühn

  4 shared

Labs

• Joshua Pierce LaboratoryPI

Similar researchers at North Carolina State University

• Jonathan Lindseyh-101
• Edward Breitschwerdth-100
• José Alonsoh-94
• Rob Dunnh-94
• Frances S. Liglerh-92