John Gladysz

About

John Gladysz is a Distinguished Professor and Dow Chair in Chemical Invention at Texas A&M University College of Arts and Sciences, Department of Chemistry. His research has traditionally centered around organometallic chemistry, with branches into catalysis, organic synthesis, enantioselective reactions, stereochemistry, mechanism, and materials chemistry. His work involves developing highly enantioselective catalysts, metal-containing organocatalysts, and recoverable catalysts that can be recycled via fluorous phases. Additionally, he synthesizes organometallic building blocks for molecular devices, including molecular wires, polygons, multistranded wires, and molecular gyroscopes and compasses. His educational background includes a B.S. from the University of Michigan and a Ph.D. from Stanford University. He has received numerous awards and honors, including the Alfred P. Sloan Foundation Fellowship, the Arthur C. Cope Scholar Award, and the Royal Society of Chemistry Award in Organometallic Chemistry. He has also served as the Editor-in-Chief of Organometallics.

Research topics

• Chemistry
• Organic chemistry
• Medicinal chemistry
• Stereochemistry
• Combinatorial chemistry
• Physics
• Computational biology
• Nanotechnology

Selected publications

• Gyroscopes and the Chemical Literature, 2002–2020: Approaches to a Nascent Family of Molecular Devices

  Chemical Reviews · 2021 · 47 citations

  Senior authorCorresponding

  Research directed toward the goal of molecular gyroscopes since the coverage of a previous review (2002) is described. Such species are a subclass of molecular rotors, which are comprised of rotators and stators. Major categories include (1) systems in which a rotator is embedded in a cage-like stator reminiscent of mechanical toy gyroscopes and (2) molecules that have been engineered to crystallize with parallel rotators and voids or other features that enable the rotator to rotate in the solid…

  DOI

• Launching Werner Complexes into the Modern Era of Catalytic Enantioselective Organic Synthesis

  Accounts of Chemical Research · 2020 · 47 citations

  Senior authorCorresponding

  ) have been evaluated. Alternatively, a dimethylamino group can be tethered to the backbone of one en ligand, providing bifunctional catalysts that obviate any need for an external base. Interestingly, the counteranions modulate the enantioselectivities somewhat. However, catalysts with chiral anions do not significantly outperform benchmark catalysts with achiral anions. Cagelike chiral hexaaminecobalt(III) complexes known as sepulchrates and sarcophagines, which feature secondary NH donor atom…

  DOI

• Chiral Tricationic Tris(1,2-diphenylethylenediamine) Cobalt(III) Hydrogen Bond Donor Catalysts with Defined Carbon/Metal Configurations; Matched/Mismatched Effects upon Enantioselectivities with Enantiomeric Chiral Counter Anions

  ACS Catalysis · 2020 · 28 citations

  Senior authorCorresponding

  The enantiopure and diastereopure salts Λ- or Δ-[Co((S,S)-dpen)3]3+ 2Cl–BArf– (Λ- or Δ-(S,S)-13+ 2Cl–BArf–; dpen/BArf = 1,2-diphenylethylenediamine/B(3,5-C6H3(CF3)2)4) and Λ-(S,S)-13+ 3Cl– are treated with salts of the enantiopure chiral monoanions (A–) or dianions (A2–) 3-bromocamphor-8-sulfonate (camphSO3–), 1,1′-binaphthyl-2,2′-diyl phosphate (and three 3,3′-disubstituted derivatives), a related biphenanthryl species, tartrate, and Sb2(tart′)22– (tart′ = [−O2C–CHO––CHO––CO2–]). The lipophilic…

  DOI

• Monodisperse Molecular Models for the sp Carbon Allotrope Carbyne; Syntheses, Structures, and Properties of Diplatinum Polyynediyl Complexes with <b>PtC₂₀Pt</b> to <b>PtC₅₂Pt</b> Linkages

  ACS Central Science · 2023-11-16 · 25 citations

  articleOpen accessSenior authorCorresponding

  Extended conjugated polyynes provide models for the elusive sp carbon polymer carbyne, but progress has been hampered by numerous synthetic challenges. Stabilities appear to be enhanced by bulky, electropositive transition-metal endgroups. Reactions of trans-(C6F5)(p-tol3P)2Pt(C≡C)nSiEt3 (n = 4–6, PtCxSi (x = 2n)) with n-Bu4N+F–/Me3SiCl followed by excess tetrayne H(C≡C)4SiEt3 (HC8Si) and then CuCl/TMEDA and O2 give the heterocoupling products PtCx+8Si, PtCx+16Si, and sometimes higher homologues…

  PublisherDOI

• Macrobicyclic Dibridgehead Di(trialkyl)pnictogens E((CH₂)_<i>n</i>)₃E (E/<i>n</i> = As/10, As/12, As/14, Sb/14) and Their Cage-like Metal Complexes: Syntheses, Structures, and Homeomorphic Isomerizations

  Organometallics · 2024-05-21 · 5 citations

  articleOpen accessSenior authorCorresponding

  Photolyses of trans-Fe(CO)3(As((CH2)n)3As) (n = a, 10; b, 12; c, 14) in the presence of PMe3, or reactions of trans-[Fe(CO)2(NO)(As((CH2)n)3As)]+ BF4– and n-Bu4N+ Cl–, afford the air stable title complexes As((CH2)n)3As (8a–c) in 79–34% yields. With 8a, the in, in and out, out isomers are separable and each is crystallographically characterized. With 8b,c, the isomers rapidly interconvert by homeomorphic isomerization, but each crystallizes (contrathermodynamically) as an out, out isomer. Reacti…

  PublisherDOI

Recent grants

• Complexes in which sp Carbon Chains span two Metals

  NSF · $458k · 2007–2011

• WIRE-LIKE and GYROSCOPE-LIKE ORGANOMETALLIC COMPLEXES

  NSF · $390k · 2012–2017

• Chemistry of Transition Metal/Main Group Element Compounds

  NSF · $495k · 1994–1998

Frequent coauthors

• Frank Hampel

  Friedrich-Alexander-Universität Erlangen-Nürnberg

  237 shared

• Nattamai Bhuvanesh

  Texas A&M University

  182 shared

• Joseph H. Reibenspies

  125 shared

• Atta M. Arif

  102 shared

• Nattamai Bhuvanesh

  85 shared

• Haijun Jiao

  Leibniz Institute for Catalysis

  71 shared

• Sławomir Szafert

  University of Wrocław

  69 shared

• Andreas Ehnbom

  63 shared

Education

• Ph.D., Organic Chemistry

  Stanford University

  1974

• B.S. Chem, Chemistry

  University of Michigan

  1971

Awards & honors

• Alfred P. Sloan Foundation Fellow 1980-1984
• Camille and Henry Dreyfus Teacher-Scholar 1980-1985
• Arthur C. Cope Scholar Award (American Chemical Society) 198…
• University of Utah Distinguished Research Award 1992
• American Chemical Society Award in Organometallic Chemistry…

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