John F. Valentine
· ProfessorUniversity of Utah · Gastroenterology & Hepatology
Active 1826–2025
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About
John F. Valentine, MD, is a Professor of Medicine at the University of Utah School of Medicine in the Division of Gastroenterology, Hepatology and Nutrition. He specializes in ulcerative colitis and Crohn's disease, with clinical interests and expertise in inflammatory diseases of the intestinal tract, including inflammatory bowel disease (IBD) and celiac disease. Dr. Valentine received his M.D. degree from the University of Texas Medical School at Houston in 1985, and completed his training in Internal Medicine at the Medical College of Virginia-Virginia Commonwealth University Medical Center, followed by Gastroenterology training at the University of Florida. While on faculty at the University of Florida, he rose to the position of Professor of Medicine, served as the Chief of the Gastroenterology Section at the Malcolm Randal Veterans Administration Medical Center, and founded the Southeastern Center for Inflammatory Bowel Disease. He remains active with the Crohn's and Colitis Foundation of America, having served as Co-Chair of the CCFA patient education committee and as a member of the editorial board for the journal Inflammatory Bowel Disease. Dr. Valentine is a Fellow in the American Gastroenterological Association and is the director of the University of Utah Inflammatory Bowel Disease Center. He has extensive experience in treating patients with inflammatory bowel disease and is involved in developing laboratory research and clinical trials in ulcerative colitis and…
Research topics
- Medicine
- Genetics
- Gastroenterology
- Internal medicine
- Biology
- Immunology
- Machine Learning
- Computational biology
- Computer Science
- Pathology
Selected publications
Gastroenterology · 2021 · 284 citations
Adaptive immunity induces mutualism between commensal eukaryotes
Nature · 2021 · 200 citations
Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn’s Disease (EXPLORER)
Clinical Gastroenterology and Hepatology · 2023-09-22 · 86 citations
articleOpen accessBACKGROUND & AIMS: Although biologics have revolutionized the treatment of Crohn's disease (CD), an efficacy ceiling has been reached. Combining biologic therapies may improve remission rates. METHODS: EXPLORER, a phase 4, single-arm, open-label study, evaluated triple combination therapy with vedolizumab (300 mg on day 1, weeks 2 and 6, and then every 8 weeks), adalimumab (160 mg on day 2, 80 mg at week 2, then 40 mg every 2 weeks), and methotrexate (15 mg weekly) in biologic-naïve patients wit…
The Lancet. Gastroenterology & hepatology · 2022-10-12 · 70 citations
articleThe American Journal of Human Genetics · 2021 · 43 citations
Recent grants
NIH · $723k · 2003
NIH · $1.6M · 2011
Frequent coauthors
- 360 shared
Beth S. Slomine
Kennedy Krieger Institute
- 288 shared
Richard Holubkov
University of Utah
- 288 shared
James R. Christensen
Johns Hopkins University
- 288 shared
Frank W. Moler
University of Michigan–Ann Arbor
- 216 shared
J. Michael Dean
University of Utah
- 216 shared
Faye S. Silverstein
University of Michigan–Ann Arbor
- 202 shared
Kathryn A. Peterson
University of Utah
- 202 shared
Kajsa E. Affolter
University of Utah
Education
- 1985
M.D.
University of Texas Medical School at Houston
Other, Internal Medicine
Medical College of Virginia-Virginia Commonwealth University Medical Center
Other, Gastroenterology
University of Florida
Awards & honors
- Fellow in the American Gastroenterological Association
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