About

Jennifer G. Barrett, DVM, PhD, DACVS, DACVSMR, is the Theodora Ayer Randolph Professor of Equine Surgery at the Marion duPont Scott Equine Medical Center, part of the Virginia-Maryland College of Veterinary Medicine at Virginia Tech. Her research interests focus on tendon, ligament, and cartilage healing, as well as stem cell and platelet-rich plasma therapies and tissue regeneration. Dr. Barrett earned her DVM from Cornell University in 2002, her Ph.D. in Molecular, Cellular, and Developmental Biology from Yale University in 1999, and holds a Master of Science and M.Phil. in Biology from Yale, as well as an A.B. in Biology from Dartmouth College. She has professional experience as an assistant, associate, and full professor of equine surgery, with her current role established in 2014. Her professional memberships include the North American Veterinary Regenerative Medicine Society, Orthopaedic Research Society, American College of Veterinary Surgeons, and others. Dr. Barrett has received awards such as the Zoetis Award for Veterinary Research Excellence in 2017 and the Clinical Research Award from the NIH in 2013-2017. Her work is dedicated to advancing knowledge in equine surgery, regenerative medicine, and tissue healing.

Research topics

• Biology
• Environmental science
• Ecology
• Agroforestry
• Soil science
• Immunology
• Chemistry
• Genetics

Selected publications

• Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells

  Nature Communications · 2022 · 73 citations

  • Biology
  • Immunology
  • Genetics

  clones, are prominent features of T-LGLL cells. Apoptosis genes are upregulated after alemtuzumab treatment, especially in responders than non-responders; baseline expression levels of apoptosis genes are predictive of hematologic response. Alemtuzumab does not attenuate TCR clonality, and TCR diversity is further skewed after treatment. Inferences made from analysis of single cell data inform understanding of the pathophysiologic mechanisms of clonal expansion and persistence in T-LGLL.

  DOI

• Historical land use has long-term effects on microbial community assembly processes in forest soils

  ISME Communications · 2021 · 94 citations

  Senior authorCorresponding
  • Environmental science
  • Agroforestry
  • Soil science

  Land use change has long-term effects on the structure of soil microbial communities, but the specific community assembly processes underlying these effects have not been identified. To investigate effects of historical land use on microbial community assembly, we sampled soils from several currently forested watersheds representing different historical land management regimes (e.g., undisturbed reference, logged, converted to agriculture). We characterized bacterial and fungal communities using amplicon sequencing and used a null model approach to quantify the relative importance of selection, dispersal, and drift processes on bacterial and fungal community assembly. We found that bacterial communities were structured by both selection and neutral (i.e., dispersal and drift) processes, while fungal communities were structured primarily by neutral processes. For both bacterial and fungal communities, selection was more important in historically disturbed soils compared with adjacent undisturbed sites, while dispersal processes were more important in undisturbed soils. Variation partitioning identified the drivers of selection to be changes in vegetation communities and soil properties (i.e., soil N availability) that occur following forest disturbance. Overall, this study casts new light on the effects of historical land use on soil microbial communities by identifying specific environmental factors that drive changes in community assembly.

  DOI

• Abundance and functional importance of complete ammonia-oxidizing bacteria (comammox) versus canonical nitrifiers in temperate forest soils

  Soil Biology and Biochemistry · 2020 · 82 citations

  Senior authorCorresponding
  • Ecology
  • Environmental science
  • Biology
  DOI

Recent grants

• Collaborative Research: The Role of Snow Patches on the Spatial Distribution of Soil Microbial Communities and Biogeochemical Cycling in the Antarctic Dry Valleys

  NSF · $244k · 2009–2012

• Dissertation Research: Do the concomitant effects of pH and ammonium concentration on ammonia availability explain differential ammonia oxidation by bacteria and archaea?

  NSF · $15k · 2012–2014

• Dissertation Research: The influence of resource gradients on soil bacterial communities in a simple ecosystem

  NSF · $15k · 2012–2014

• NIH Grant R01DA002873

  NIH · $1.2M · 1993

• Collaborative Research: Controls over the Spatial Distribution and Activity of Microbial Communities in Antarctic Soils

  NSF · $199k · 2010–2014

Frequent coauthors

• M. N. Gooseff

  Institute of Arctic and Alpine Research

  55 shared

• Peter M. Brophy

  Aberystwyth University

  48 shared

• Ross A. Virginia

  Dartmouth College

  46 shared

• Diana H. Wall

  42 shared

• Byron J. Adams

  Brigham Young University

  30 shared

• Cristina Takacs‐Vesbach

  30 shared

• Eric R. Sokol

  26 shared

• S. Craig Cary

  University of Waikato

  26 shared

Labs

• Virginia-Maryland College of Veterinary MedicinePI

Education

• Other, Veterinary Medicine

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• Ph.D., Not specified in the provided HTML

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Awards & honors

• Zoetis Award for Veterinary Research Excellence (2017)
• Clinical Research Award, LRP National Institutes of Health (…

Similar researchers at Virginia Tech

• Dennis R. Deanh-102
• Wenjing Louh-77
• Pendleton R. Montagueh-77
• Romesh Batrah-74
• Marc A. Edwardsh-73