About

Gha-hyun Jeffrey Kim, PharmD PhD, is an Assistant Professor in the Department of Clinical Pharmacy Practice at UC Irvine School of Pharmacy and Pharmaceutical Sciences. He holds a PharmD from UCSF and a PhD in Pharmaceutical Science and Pharmacogenomics from UCSF. Dr. Kim's research spans computational pharmacogenomics, neurodegenerative disease modeling, and AI-driven biomedical data science. Prior to his current position, he was a scientist at Color Genomics and an affiliate researcher at UC San Francisco.

Research topics

• Internal medicine
• Medicine
• Biology
• Surgery
• Oncology
• Pharmacology
• Intensive care medicine
• Chemistry
• Radiology
• Composite material
• Pathology
• Cancer research
• Cell biology
• Biochemistry
• Materials science

Selected publications

• Lung Cancer: Diagnosis, Treatment Principles, and Screening.

  PubMed · 2022 · 98 citations

  1st authorCorresponding
  • Medicine
  • Intensive care medicine
  • Internal medicine

  Lung cancer is the second most common cancer in men and women in the United States; however, it remains the leading cause of cancer-related death in the United States and worldwide. The most common but nonspecific symptom of lung cancer is cough. Associated symptoms, including hemoptysis or shortness of breath, or systemic symptoms, including anorexia or weight loss, greatly increase the likelihood of having lung cancer. Referral to a multidisciplinary lung cancer team, imaging, and confirmation through sputum cytology, thoracentesis, fine-needle aspiration, or mediastinoscopy are recommended. If lung cancer is confirmed, treatment options vary based on staging, histology, immunotherapy biomarker testing, and patient health status. Treatments include surgical resection, immunotherapy, chemotherapy, and/or radiotherapy. Family physicians should focus on primary prevention of lung cancer by encouraging tobacco cessation and early recognition by screening at-risk individuals and following guidelines for pulmonary nodules. As of 2021, the U.S. Preventive Services Task Force recommends annual lung cancer screening using low-dose computed tomography starting at 50 years of age in patients with a 20 pack-year history.

• Increased PD-L1 and p16 Expression are Common in Oropharyngeal Squamous Cell Carcinoma

  Future Science OA · 2021 · 7 citations

  • Medicine
  • Pathology
  • Cancer research

  Overexpression of p16 is closely related to human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) and pertains a prognostic relevance. Programmed cell death 1-ligand 1 (PD-L1) is another important marker, as anti-PD-L1 immunotherapy is available. Retrospective analysis of 57 cases of the SCC involving oropharynx (27 cases), hypopharynx (5 cases), larynx (11 cases), and oral cavity (14 cases) was performed. Each case was scrutinized for the basaloid morphology, p16, and PD-L1 expression. Basaloid morphology was identified in 47% of total cases. The majority of basaloid SCC variants were located in the oropharynx (89%). High expression of p16 was mostly observed in the oropharynx. High PD-L1 expression was seen predominantly in oropharyngeal and hypopharyngeal locations. Further studies in a larger cohort are necessary to correlate PD-L1 and p16 expression with survival.

  PublisherDOI

• Hybrid carbon nanotube - carbon fiber composites for high damping

  Composites Science and Technology · 2021 · 33 citations

  1st authorCorresponding
  • Materials science
  • Composite material
  DOI

• Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

  Clinical and Translational Science · 2020 · 49 citations

  • Pharmacology
  • Medicine
  • Chemistry

  for paclitaxel reduction of neurite area was 1.4 µM (95% CI 0.3-16.9 µM) for 48-hour exposure and 0.6 µM (95% CI 0.09-9.9 µM) for 72-hour exposure. Decreased mitochondrial membrane potential, slower movement of mitochondria down the neurites, and changes in glutamate-induced neuronal excitability were also observed with paclitaxel exposure. The iPSC-SNs were also sensitive to docetaxel, vincristine, and bortezomib. Collectively, these data support the use of iPSC-SNs for detailed mechanistic investigations of genes and pathways implicated in chemotherapy-induced neurotoxicity and the identification of novel therapeutic approaches for its prevention and treatment.

  DOI

Frequent coauthors

• Jamie A. Decker

  Johns Hopkins University

  32 shared

• Susan W. Denfield

  31 shared

• Jack F. Price

  Pride Foundation

  28 shared

• Santiago O. Valdés

  Texas Children's Hospital

  24 shared

• Bruce A. Watkins

  University of California, Davis

  24 shared

• Joseph W. Rossano

  Children's Hospital of Philadelphia

  24 shared

• William J. Dreyer

  Baylor College of Medicine

  21 shared

• John L. Jefferies

  University of Tennessee Health Science Center

  20 shared

Labs

• Kim LabPI

Education

• B.S., Biology

  University of California San Diego

  2012

• Other

  University of California San Francisco

  2016

• Ph.D., Pharmaceutical Sciences and Pharmacogenomics

  University of California San Francisco

  2021

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• Alex B Guentherh-131