Isabel Gimeno

About

Isabel Gimeno is an Associate Professor in the Department of Population Health and Pathobiology at the College of Veterinary Medicine, North Carolina State University, a position she has held since July 2012. Her educational background includes a PhD in Veterinary Pathology from Universidad Complutense de Madrid, earned in 1999, and she is a Diplomate of the American College of Poultry Veterinarians. Her expertise centers on global health and infectious diseases, with a particular focus on Marek's disease in poultry. Her research aims to understand the mechanisms of vaccine immunity against Marek's disease virus (MDV), especially as more virulent strains emerge, and to develop more effective vaccines. She has contributed to establishing diagnostic criteria and molecular techniques for tumor viral diseases in poultry, including real-time PCR assays for early diagnosis and vaccination monitoring. Her work also explores the pathogenesis of MDV in the nervous system, investigating immune responses and autoimmunity related to the disease.

Research topics

• Virology
• Biology
• Immunology
• Genetics

Selected publications

• Virus-Induced Immunosuppression in Chickens

  Avian Diseases · 2018-09-01 · 129 citations

  review1st authorCorresponding

  A healthy immune system is a cornerstone for poultry production. Any factor diminishing the immune responses will affect production parameters and increase cost. There are numerous factors, infectious and noninfectious, causing immunosuppression (IS) in chickens. This paper reviews the three viral diseases that most commonly induce IS or subclinical IS in chickens: Marek's disease virus (MDV), chicken infectious anemia virus (CIAV), and infectious bursal disease virus (IBDV), as well as the inte…

  PublisherDOI

• Neoplastic Diseases

  2019-11-22 · 34 citations

  other
  PublisherDOI

• Effect of Marek’s disease vaccines on interferon and toll like receptors when administered in ovo

  Veterinary Immunology and Immunopathology · 2018-05-24 · 14 citations

  article1st authorCorresponding
  PublisherDOI

• Highly virulent Marek’s disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens

  Avian Pathology · 2019-07-11 · 12 citations

  articleOpen access1st authorCorresponding

  In previous studies, we have demonstrated that very virulent plus Marek’s disease viruses (vv+MDV) are highly immunosuppressive in commercial meat-type chickens. The specific objectives of this work were to evaluate if vv+MDV immunosuppression (MDV-IS) is induced by reduction of lymphocyte responsiveness and/or viability. Three experiments were conducted to (i) compare vv+MDV 686 with a partially attenuated 686-BAC; (ii) compare vv+MDV strains (648A and 686) with vMDV (GA) and vvMDV (Md5); and (…

  PublisherOA PDFDOI

• Differential attenuation of Marek’s disease virus-induced tumours and late-Marek’s disease virus-induced immunosuppression

  Journal of General Virology · 2018-05-16 · 10 citations

  articleSenior author

  Marek’s disease virus (MDV) is a herpesvirus that induces lymphoma and a variety of non-neoplastic syndromes in chickens. Furthermore, very virulent plus (vv+) MDVs induce a form of immunosuppression (late-MDV-IS) that might involve both neoplastic and non-neoplastic mechanisms. The objective of this study was to evaluate whether the attenuation of MDV-induced tumours and late-MDV-IS occurs simultaneously or can be dissociated. The immunosuppressive ability of three viruses derived from vv+ MDV…

  PublisherDOI

Frequent coauthors

• Aneg L. Cortes

  North Carolina State University

  42 shared

• R. L. Witter

  35 shared

• Arun R. Pandiri

  National Institute of Environmental Health Sciences

  21 shared

• Pedro Tauler

  Health Research Institute of the Balearic Islands

  20 shared

• Antoni Pons

  Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition

  20 shared

• Sanjay M. Reddy

  Texas A&M University

  19 shared

• Antoni Aguiló

  Research Institute of Health Sciences

  19 shared

• Nik M. Faiz

  Universiti Putra Malaysia

  17 shared

Awards & honors

• 2016 AAAP Awards

Similar researchers at North Carolina State University

• Luke Borsth-37
• Siddhartha Thakurh-36
• Casey Therioth-35