Gerard A. Ateshian

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

Science Translational Medicine · 2020 · 54 citations

Joint disorders can be detrimental to quality of life. There is an unmet need for precise functional reconstruction of native-like cartilage and bone tissues in the craniofacial space and particularly for the temporomandibular joint (TMJ). Current surgical methods suffer from lack of precision and comorbidities and frequently involve multiple operations. Studies have sought to improve craniofacial bone grafts without addressing the cartilage, which is essential to TMJ function. For the human-siz…

Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena

Journal of Biomechanical Engineering · 2020 · 31 citations

The osmotic pressure in articular cartilage serves an important mechanical function in healthy tissue. Its magnitude is thought to play a role in advancing osteoarthritis. The aims of this study were to: (1) isolate and quantify the magnitude of cartilage swelling pressure in situ; and (2) identify the effect of salt concentration on material parameters. Confined compression stress-relaxation testing was performed on 18 immature bovine and six mature human cartilage samples in solutions of varyi…

Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs

Biotechnology and Bioengineering · 2020 · 28 citations

Articular cartilage injuries are a common source of joint pain and dysfunction. We hypothesized that pulsed electromagnetic fields (PEMFs) would improve growth and healing of tissue-engineered cartilage grafts in a direction-dependent manner. PEMF stimulation of engineered cartilage constructs was first evaluated in vitro using passaged adult canine chondrocytes embedded in an agarose hydrogel scaffold. PEMF coils oriented parallel to the articular surface induced superior repair stiffness compa…

Finite Element Implementation of Biphasic-Fluid Structure Interactions in <scp>febio</scp>

Journal of Biomechanical Engineering · 2021 · 15 citations

In biomechanics, solid-fluid mixtures have commonly been used to model the response of hydrated biological tissues. In cartilage mechanics, this type of mixture, where the fluid and solid constituents are both assumed to be intrinsically incompressible, is often called a biphasic material. Various physiological processes involve the interaction of a viscous fluid with a porous-hydrated tissue, as encountered in synovial joint lubrication, cardiovascular mechanics, and respiratory mechanics. The…

A hybrid biphasic mixture formulation for modeling dynamics in porous deformable biological tissues

Archive of Applied Mechanics · 2021 · 15 citations