Ferric Fang

COVID-19—Lessons Learned and Questions Remaining

Clinical Infectious Diseases · 2020 · 84 citations

In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2 infection and identify essential questions about COVID-19 that remain to be answered.

The Laboratory Diagnosis of Coronavirus Disease 2019— Frequently Asked Questions

Clinical Infectious Diseases · 2020 · 77 citations

Diagnostic testing has played and will continue to play a major role in the coronavirus disease 2019 (COVID-19) pandemic. The ability to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory secretions is essential to determine when an individual is infected and potentially infectious to others. Viral detection is used for the identification, management, and isolation of individual patients. Viral detection is also used to determine when the virus has entered a commu…

Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays

Journal of Clinical Virology · 2022 · 60 citations

Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in <i>Neisseria gonorrhoeae</i> and Colonization With Tetracycline-Resistant <i>Staphylococcus aureus</i> and Group A <i>Streptococcus</i>

Clinical Infectious Diseases · 2025-02-27 · 38 citations

BACKGROUND: Doxycycline post-exposure prophylaxis (doxy PEP) is increasingly used among men who have sex with men (MSM). Its impact on antimicrobial resistance and the microbiome is uncertain. METHODS: We used Neisseria gonorrhoeae (NG) surveillance data from King County, Washington, USA, and joinpoint regression to investigate trends in NG-tetracycline resistance (tetR), 2017-2024 and, among sexual health clinic (SHC) patients, evaluated the association of NG-tetR with doxy PEP use. We evaluate…

Nuclear factor kappa B-dependent persistence of <i>Salmonella</i> Typhi and Paratyphi in human macrophages

mBio · 2024-04-10 · 14 citations

ABSTRACT Salmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric fever Salmonella infections have remained elusive. Here, we show that S . Typhi and S . Paratyphi A can persist within human macrophages, whereas S . Typhimurium rapidly induces apoptotic macrophage cell death that is dependent on Salmonella pathogenicity…