David Fredricks

About

David Fredricks is a faculty member in the Department of Laboratory Medicine & Pathology at UW Medicine, University of Washington. The department is recognized for its excellence in clinical training, research initiatives, and community service, serving the five-state WWAMI region. While the specific details of Dr. Fredricks' research focus and background are not provided in the page text, he is associated with a department that combines sophisticated testing and informatics capabilities with academic resources to deliver clinical and anatomical pathology services. The department emphasizes innovative patient care, research, and education, and is involved in expanding diagnostic testing such as measles testing to support public health responses.

Research topics

• Biology
• Medicine
• Internal medicine
• Virology
• Microbiology
• Genetics
• Ecology
• Gynecology

Selected publications

• Complementing 16S rRNA Gene Amplicon Sequencing with Total Bacterial Load To Infer Absolute Species Concentrations in the Vaginal Microbiome

  mSystems · 2020 · 96 citations

  Microbiome studies primarily use 16S rRNA gene amplicon sequencing to assess the relative abundance of bacterial taxa in a community. However, these measurements do not accurately reflect absolute taxon concentrations. We sought to determine whether the product of species' relative abundance and total bacterial load measured by broad-range qPCR is an accurate proxy for individual species' concentrations, as measured by taxon-specific qPCR assays. Overall, the inferred bacterial concentrations we…

  DOI

• Urethral Microbiota in Men: Association of <i>Haemophilus influenzae</i> and <i>Mycoplasma penetrans</i> With Nongonococcal Urethritis

  Clinical Infectious Diseases · 2020 · 57 citations

  BACKGROUND: Nongonococcal urethritis (NGU) is a common syndrome with no known etiology in ≤50% of cases. We estimated associations between urethral bacteria and NGU in men who have sex with men (MSM) and men who have sex with women (MSW). METHODS: Urine was collected from NGU cases (129 MSM, 121 MSW) and controls (70 MSM, 114 MSW) attending a Seattle STD clinic. Cases had ≥5 polymorphonuclear leukocytes on Gram stain plus symptoms or discharge; controls had <5 PMNs, no symptoms, no discharge. NG…

  DOI

• Vaginal Bacteria and Proinflammatory Host Immune Mediators as Biomarkers of Human Immunodeficiency Virus Acquisition Risk Among African Women

  The Journal of Infectious Diseases · 2024-09-09 · 11 citations

  articleOpen access

  BACKGROUND: Few investigations have assessed contributions of both vaginal bacteria and proinflammatory immune mediators to human immunodeficiency virus (HIV) acquisition risk in a prospective cohort. METHODS: We conducted a nested case-control study of African women who participated in a randomized placebo-controlled trial of daily oral versus vaginal tenofovir-based preexposure prophylaxis for HIV infection. Vaginal concentrations of 23 bacterial taxa and 16 immune mediators were measured. Rel…

  PublisherOA PDFDOI

• A prospective cohort study examining the association between the periconceptual vaginal microbiota and first‐trimester miscarriage in Kenyan women

  Paediatric and Perinatal Epidemiology · 2024-07-01 · 4 citations

  articleOpen accessSenior author

  BACKGROUND: Studies evaluating the association between the vaginal microbiota and miscarriage have produced variable results. OBJECTIVE: This study evaluated the association between periconceptual and first-trimester vaginal microbiota and women's risk for miscarriage. METHODS: At monthly preconception visits and at 9-12 weeks gestation, women collected vaginal swabs for molecular characterisation of the vaginal microbiota. Participants who became pregnant were followed to identify miscarriage v…

  PublisherOA PDFDOI

• Bacterial Vaginosis Is Associated With Transcriptomic Changes but Not Higher Concentrations of Cervical Leukocytes in a Study of Women at High Risk for Human Immunodeficiency Virus Acquisition

  The Journal of Infectious Diseases · 2025-01-28 · 3 citations

  articleOpen access

  BACKGROUND: The association between bacterial vaginosis (BV) and increased human immunodeficiency virus (HIV) acquisition risk may be related to concentrations of HIV-susceptible immune cells in the cervix. METHODS: Participants (31 with BV and 30 with normal microbiota) underwent cervical biopsy at a single visit. Immune cells were quantified and sorted using flow cytometry (n = 55), localization assessed by immunofluorescence (n = 16), and function determined by bulk RNA sequencing (RNA-seq) o…

  PublisherOA PDFDOI

Recent grants

• The Gut Microbiota and Graft versus Host Disease (GVHD)

  NIH · $4.0M · 2017–2023

• NIH Grant K11AI001360

  NIH · $325k · 2001

• NIH Grant R21AI091970

  NIH · $480k · 2014

Frequent coauthors

• Sujatha Srinivasan

  Fred Hutch Cancer Center

  309 shared

• Tina L. Fiedler

  Fred Hutch Cancer Center

  208 shared

• Congzhou Liu

  Fred Hutch Cancer Center

  148 shared

• Steven A. Pergam

  University of Washington

  98 shared

• Jennifer E. Balkus

  University of Washington

  90 shared

• Sean Proll

  Fred Hutch Cancer Center

  78 shared

• Jeanne Marrazzo

  University of Alabama at Birmingham

  75 shared

• Michael Boeckh

  Fred Hutch Cancer Center

  72 shared

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