Eugene B. Chang

About

Eugene B. Chang is the Martin Boyer Professor of Medicine at the University of Chicago, affiliated with the Department of Medicine. His research group focuses on studying intestinal microbes and their interactions with the host, emphasizing the importance of the microbiome in human health. Dr. Chang's work explores how environmental and lifestyle changes over the past century may have altered the human microbiome, contributing to the rise of disorders such as diabetes, obesity, metabolic syndrome, cancer, and autoimmune diseases. His research aims to understand the factors influencing the assembly of intestinal microbial communities and to harness this knowledge for disease prevention and treatment. Employing advanced microbial analysis, genetically modified and gnotobiotic mouse models, metabolic profiling, and bioinformatics, Dr. Chang's lab investigates both host and microbiome dynamics. He is actively involved in multiple academic committees, including Cancer Biology, Immunology, Microbiology, and Molecular Metabolism and Nutrition, and has received several awards for his contributions to the field.

Research topics

• Biology
• Immunology
• Medicine
• Internal medicine
• Bioinformatics
• Microbiology
• Sociology
• Biochemistry
• Pathology
• Neuroscience

Selected publications

• Inflammatory Bowel Diseases (IBD) and the Microbiome—Searching the Crime Scene for Clues

  Gastroenterology · 2020 · 657 citations

  Senior authorCorresponding
  DOI

• The Gut Microbiome and Inflammatory Bowel Diseases

  Annual Review of Medicine · 2021 · 381 citations

  Senior authorCorresponding

  Inflammatory bowel diseases (IBD) arise from a convergence of genetic risk, environmental factors, and gut microbiota, where each is necessary but not sufficient to cause disease. Emerging evidence supports a bidirectional relationship between disease progression and changes in microbiota membership and function. Thus, the study of the gut microbiome and host-microbe interactions should provide critical insights into disease pathogenesis as well as leads for developing microbiome-based diagnosti…

  DOI

• Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

  The Journal of Experimental Medicine · 2020 · 376 citations

  Most studies focus on how intestinal microbiota influence cancer immunotherapy through activating gut immunity. However, immunotherapies related to innate responses such as CD47 blockade rely on the rapid immune responses within the tumor microenvironment. Using one defined anaerobic gut microbiota to track whether microbiota interact with host immunity, we observed that Bifidobacterium facilitates local anti-CD47 immunotherapy on tumor tissues through the capacity to accumulate within the tumor…

  DOI

• Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

  Nature Reviews Gastroenterology & Hepatology · 2021 · 179 citations

  Senior authorCorresponding
  PublisherOA PDFDOI

• Noninvasive, microbiome-based diagnosis of inflammatory bowel disease

  Nature Medicine · 2024-10-04 · 111 citations

  articleOpen access

  Despite recent progress in our understanding of the association between the gut microbiome and inflammatory bowel disease (IBD), the role of microbiome biomarkers in IBD diagnosis remains underexplored. Here we developed a microbiome-based diagnostic test for IBD. By utilization of metagenomic data from 5,979 fecal samples with and without IBD from different geographies and ethnicities, we identified microbiota alterations in IBD and selected ten and nine bacterial species for construction of di…

  PublisherDOI

Recent grants

• NIH Grant R01DK047722

  NIH · $5.6M · 2022

• NIH Grant R21HG004858

  NIH · $414k · 2010

• NIH Grant R01DK040922

  NIH · $532k · 1992

Frequent coauthors

• Mark W. Musch

  University of Chicago

  183 shared

• Yunwei Wang

  Liuzhou General Hospital

  89 shared

• Jack A. Gilbert

  University of California, San Diego

  88 shared

• Vanessa Leone

  University of Wisconsin–Madison

  75 shared

• Mrinalini C. Rao

  University of Illinois Chicago

  58 shared

• Casey T. Weaver

  University of Alabama at Birmingham

  49 shared

• Kristen L. Dennis

  49 shared

• Shuya Wang

  Central South University

  49 shared

Labs

• Eugene B. Chang LabPI

Awards & honors

• Takeda Distinguished Scientist Award Takeda, Inc. (2014)
• National Diabetes and Digestive and Kidney Disease Advisory…
• AGA Outstanding Mentorship award American Gastroenterologica…
• NIH Merit Award National Institutes of Health (2008 - 2018)

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