About
Dustin J. Maly, Ph.D., is the Principal Investigator and Raymon E. and Rosellen M. Lawton Endowed Professor of Chemistry at the University of Washington, Seattle, Department of Chemistry. His research focuses on using organic synthesis to generate small molecules aimed at controlling the growth of prostate cancers. Additionally, he employs chemical proteomics techniques to identify the molecular targets of these small molecules. This integrated approach combines synthetic chemistry and proteomic analysis to advance understanding and potential therapeutic strategies for prostate cancer. Outside of his professional work, Professor Maly enjoys reading, driving, and traveling.
Research topics
- Biology
- Computational biology
- Genetics
- Pharmacology
- Cell biology
- Computer Science
- Internal medicine
- Medicine
- Immunology
- Bioinformatics
Selected publications
Nature Communications · 2020 · 58 citations
CRISPR-Cas9 nucleases are powerful genome engineering tools, but unwanted cleavage at off-target and previously edited sites remains a major concern. Numerous strategies to reduce unwanted cleavage have been devised, but all are imperfect. Here, we report that off-target sites can be shielded from the active Cas9•single guide RNA (sgRNA) complex through the co-administration of dead-RNAs (dRNAs), truncated guide RNAs that direct Cas9 binding but not cleavage. dRNAs can effectively suppress a wid…
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
International Journal for Parasitology · 2020 · 49 citations
Cell Systems · 2020 · 40 citations
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Molecular Cell · 2023 · 35 citations
Veterinary Parasitology · 2020 · 32 citations
Recent grants
Target identification by small-molecule labeling in live cells
NIH · $425k · 2014–2017
Discovery and validation of new kinase drug targets in T. brucei
NIH · $1.6M · 2014–2019
New Molecular Probes For Protein Kinases
NIH · $5.5M · 2008–2027
Frequent coauthors
- 151 shared
Kayode K. Ojo
- 149 shared
Wesley C. Van Voorhis
- 130 shared
Ryan Choi
- 128 shared
B. Gayani K. Perera
- 125 shared
Lynn K. Barrett
- 125 shared
Matthew A. Hulverson
- 117 shared
Grant R. Whitman
- 114 shared
Samuel L.M. Arnold
University of Washington
Labs
Maly LabPI
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