Douglas Antczak

About

Douglas Antczak is a professor emeritus of Microbiology and Immunology at Cornell University College of Veterinary Medicine. He received his Doctor of Veterinary Medicine (DVM) degree from the University of Montreal in Canada and was awarded a Ph.D. in Veterinary Microbiology from Texas A&M University for his studies on the outer membrane proteins of Brucella spp. His research interests include the pathogenesis of bacterial diseases affecting mammalian and aquatic animals. He has a background working as a postdoctoral fellow in the laboratory of Dr. Daniel Portnoy at the University of Pennsylvania, focusing on the pathogenesis of Listeria monocytogenes. His professional career includes an assistant professorship at the University of Colorado School of Medicine before moving to Cornell University in July 2001. Throughout his career, he has contributed to the understanding of bacterial disease mechanisms and has been involved in microbiology and immunology research.

Research topics

• Biology
• Genetics
• Medicine
• Pathology
• Geography
• Immunology
• Evolutionary biology
• Cell biology
• Cancer research
• Computational biology

Selected publications

• Prediction of histone post-translational modification patterns based on nascent transcription data

  Nature Genetics · 2022 · 111 citations

  PublisherOA PDFDOI

• Genome Diversity and the Origin of the Arabian Horse

  Scientific Reports · 2020 · 89 citations

  The Arabian horse, one of the world's oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabian horses from 12 countries using equine single nucleotide polymorphism (SNP) arrays and whole-genome re-sequencing to examine hypotheses about genomic diversity, population structure, and the relationship of t…

  PublisherOA PDFDOI

• Y-Chromosomal Insights into Breeding History and Sire Line Genealogies of Arabian Horses

  Genes · 2022-01-26 · 49 citations

  articleOpen access

  The Y chromosome is a valuable genetic marker for studying the origin and influence of paternal lineages in populations. In this study, we conducted Y-chromosomal lineage-tracing in Arabian horses. First, we resolved a Y haplotype phylogeny based on the next generation sequencing data of 157 males from several breeds. Y-chromosomal haplotypes specific for Arabian horses were inferred by genotyping a collection of 145 males representing most Arabian sire lines that are active around the globe. Th…

  PublisherOA PDFDOI

• Refining the evolutionary tree of the horse Y chromosome

  Scientific Reports · 2023-06-02 · 39 citations

  articleOpen access

  The Y chromosome carries information about the demography of paternal lineages, and thus, can prove invaluable for retracing both the evolutionary trajectory of wild animals and the breeding history of domesticates. In horses, the Y chromosome shows a limited, but highly informative, sequence diversity, supporting the increasing breeding influence of Oriental lineages during the last 1500 years. Here, we augment the primary horse Y-phylogeny, which is currently mainly based on modern horse breed…

  PublisherOA PDFDOI

• Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

  Stem Cells Translational Medicine · 2020 · 38 citations

  Allogeneic mesenchymal stromal cells (MSCs) have been used clinically for decades, without cross-matching, on the assumption that they are immune-privileged. In the equine model, we demonstrate innate and adaptive immune responses after repeated intra-articular injection with major histocompatibility complex (MHC) mismatched allogeneic MSCs, but not MHC matched allogeneic or autologous MSCs. We document increased peri-articular edema and synovial effusion, increased synovial cytokine and chemoki…

  PublisherDOI

Recent grants

• NIH Grant R01HD034086

  NIH · $660k · 2001

• NIH Grant R01HD015799

  NIH · $2.1M · 2002

• NIH Grant R01HD049545

  NIH · $1.3M · 2012

Frequent coauthors

• Donald C. Miller

  Cornell University

  56 shared

• T.L. Lear

  University of Kentucky

  56 shared

• Terje Raudsepp

  Texas A&M University

  55 shared

• M. M. Binns

  53 shared

• Loren C. Skow

  Texas A&M University

  53 shared

• June Swinburne

  52 shared

• Gérard Guérin

  52 shared

• L. V. Millon

  University of California, Davis

  52 shared

Labs

• Hélène Marquis LabPI

Similar researchers at Cornell University

• Satoshi Kimurah-76
• Gary Whittakerh-73
• Dwight Bowmanh-55