About

Deva Chan is the Director of Graduate Programs and an Associate Professor of Biomedical Engineering at Purdue University. His research focuses on biomedical engineering, contributing to the field through his academic leadership and research activities. Specific details about his research interests, background, or key contributions are not provided in the page text.

Research topics

• Political Science
• Engineering
• Computer Science
• Composite material
• Orthodontics
• Public relations
• Biochemistry
• Structural engineering
• Cell biology
• Chemistry
• Materials science
• Engineering ethics
• Medicine
• Geometry
• Biology
• Medical education
• Mathematics
• Biomedical engineering
• Surgery

Selected publications

• 64 Finite Element Analysis of a Porous Dual Component 3D-Printed Bone Graft for Alveolar Ridge Augmentation

  Journal of Clinical and Translational Science · 2023

  • Materials science
  • Composite material
  • Biomedical engineering

  OBJECTIVES/GOALS: Our goal was to assess the ability of a 3D-Printed dual cover-core design alveolar ridge bone graft, to withstand the average maximum masticatory force of a healthy person. To this end, we characterized the materials, ran a finite element analysis (FEA) model, and validated it using a resin 3D-printed version tested under compression with strain gauges. METHODS/STUDY POPULATION: A tricalcium-phosphate/hydroxyapatite paste and mixed methacrylated alginate-gelatin were used for the core, and polycaprolactone for the cover. These were characterized using ASTM standards D695 and D638 for compression, tensile, and rheological testing. Then we converted cone CT-scan images of a mandibular alveolar ridge defect to an .stl file, and designed the cover and core in Meshmixer. The model was then imported into ANSYS 11.0, and a downward compression force of 500 N, the maximum masticatory force of a healthy adult, was applied on the graft and mandible’s top ridge. The different models included solid and porous covers and cores, as well as comparing screws on one or both sides of the cover, then validated by compressing a resin 3D-printed versions. RESULTS/ANTICIPATED RESULTS: The FEA model provided maximum displacements, Von Mises stress (VMS), and stress/strain values for each model. The highest maximum displacement was found on the solid covers with a combination of both buccal and lingual screws, at 0.162 mm. The lowest maximum displacement was found in the porous cover at 0.085 mm. All VMS values were below the tensile yield strength, meaning that the materials would not yield. The highest maximum stress was found on the porous cover at 13.52 MPa, the lowest was 1.06 MPa on the cover with no screws. The highest strain was found on the porous model at 0.010, which was 5.6x higher than the solid cover. The porous cover also showed less stress shielding, thus allowing a beneficial mechanical stimulation of the bone, and the lowest maximum displacement, possibly due to flexion through the pores. DISCUSSION/SIGNIFICANCE: Preliminary FEA models demonstrated that for the considered materials, a cover-core design of the mandibular implant would sustain the desired 500 N of force without yielding. The porous cover provides the most benefits, causing the least stress shielding and allowing diffusion of biological factors to support the osteoinductive role of the core.

  DOI

• Diversify Your Faculty: A Roadmap for Equitable Hiring Strategies

  Research Square (Research Square) · 2022 · 1 citations

  • Political Science
  • Public relations
  • Medical education
  DOI

• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  bioRxiv (Cold Spring Harbor Laboratory) · 2022

  • Cell biology
  • Biology
  • Chemistry

  Abstract Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophillike cells via suppressing Rac activation. Here, we show that in mouse embryonic fibroblasts, MFN2 suppresses RhoA activation and supports cell polarization. After the initial spreading period, the wild-type cells polarize and migrate, whereas the Mfn2 -/- cells maintain a circular shape. Increased cytosolic Ca 2+ resulting from the loss of Mfn2 is directly responsible for this phenotype, which can be rescued by expressing an artificial tether to bring mitochondria and ER to close vicinity. Elevated cytosolic Ca 2+ activates Ca 2+ /calmodulin-dependent protein kinase II, RhoA, and Myosin light-chain kinase, causing an over-activation of non-muscle myosin II and a formation of a prominent F-actin ring at the cell periphery and increased cell contractility. The formation of the peripheral actin band alters cell physics and is dependent on substrate rigidity. Our results provide a novel molecular basis to understand how MFN2 regulates distinct signaling pathways in different cells and tissue environments, which is instrumental in understanding and treating MFN2-related diseases.

  DOI

Frequent coauthors

• Fan Xu

  Linyi University

  2 shared

• Karen L. Christman

  University of California, San Diego

  2 shared

• Qing Deng

  Purdue University West Lafayette

  2 shared

• Brian A. Aguado

  Sanford Consortium for Regenerative Medicine

  2 shared

• Richard L. Roudebush

  Purdue University System

  2 shared

• Gabriella Coloyan Fleming

  The University of Texas at Austin

  2 shared

• Ana Maria Porras

  University of Florida

  1 shared

• Laura P Cifuentes

  Purdue University West Lafayette

  1 shared

Labs

• Weldon School of Biomedical EngineeringPI

Similar researchers at Purdue University

• Masahiro Murakamih-100
• Zhixiang Chenh-87
• Anthony H Smithh-79
• Clint Chappleh-75
• Laurence B. Leonardh-74