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SC
Dr. Sarah Chen
Stanford · NLP & interpretability
91
fit
Fairness + NLP projects overlap with her recent work.
Strong methods fit: model evaluation and interpretability.
Clear outreach angle for current trustworthy AI research.
Outreach angle
Ask how her lab is extending interpretability methods into fairness audits for real-world AI systems.
Importance: Scoring systems for Stevens-Johnson syndrome and epidermal necrolysis (EN) only estimate patient prognosis and are weighted toward comorbidities and systemic features; morphologic terminology for EN lesions is inconsistent. Objectives: To establish consensus among expert dermatologists on EN terminology, morphologic progression, and most-affected sites, and to build a framework for developing a skin-directed scoring system for EN. Evidence Review: A Delphi consensus using the RAND/UCLA appropriateness criteria was initiated with a core group from the Society of Dermatology Hospitalists to establish agreement on the optimal design for an EN cutaneous scoring instrument, terminology, morphologic traits, and sites of involvement. Findings: In round 1, the 54 participating dermatology hospitalists reached consensus on all 49 statements (30 appropriate, 3 inappropriate, 16 uncertain). In round 2, they agreed on another 15 statements (8 appropriate, 7 uncertain). There was consistent agreement on the need for a skin-specific instrument; on the most-often affected skin sites (head and neck, chest, upper back, ocular mucosa, oral mucosa); and that blanching erythema, dusky erythema, targetoid erythema, vesicles/bullae, desquamation, and erosions comprise the morphologic traits of EN and can be consistently differentiated. Conclusions and Relevance: This consensus exercise confirmed the need for an EN skin-directed scoring system, nomenclature, and differentiation of specific morphologic traits, and identified the sites most affected. It also established a baseline consensus for a standardized EN instrument with consistent terminology.
( N Engl J Med . 2024;391(3):260-271. doi: 10.1056/NEJMcpc2309500) This case study documents details surrounding a hospital admission of a 30-year-old woman, 6 days after giving birth due to her symptoms of fever and abdominal pain. When the woman delivered her child, her gestational age was 35 weeks 3 days. The birth was straightforward, with spontaneous rupture of membranes, vaginal delivery of infant and placenta, with ~300 mL of blood loss. Due to the baby being born prematurely, the baby remained under hospital supervision, while the mother was discharged on day 2 after birth. On the sixth day postdelivery, the mother developed fever and chills and visited the emergency department. An examination resulted in findings of erythematous pustules with fluid drainage within the right inguinal area as well as minor leg swelling the patient noted as reduced from the day of birth. After 6 days of hospital admission, an endometrial biopsy resulted in finding neutrophilic debris. MRI and magnetic resonance angiography of the pelvic region resulted in ascites and anasarca, with increases seen days later. Following the identification of a fluid collection in the parametrium, a catheter was inserted to drain purulent fluid. On day 11 of hospital admission, the patient reported increased abdominal pain and shortness of breath. Due to an oxygen saturation of 86%, a nasal cannula was used to deliver additional oxygen to the patient. A distended abdomen and marked jugular venous distention were present as well as diffuse anasarca and ankle edema. An echocardiogram resulted in identifying abnormalities of the heart chambers, arteries, and septum. On day 12, plaques developed on the left upper arm, which subsequently ulcerated. Concurrently, new skin lesions arose within the right inguinal crease and upon the mons pubis. The development of a bulla on the left abdominal wall also occurred, which began to ulcerate over the next 2 days, with a similar lesion forming at the site of the drainage catheter. Those ulcers arising on day 12 all increased in area and depth, with a new ulcer forming in the left inguinal crease.
