Dale Whittington

About

Dale Whittington is a Manager & Technical Director and Teaching Associate in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. He is involved with the Mass Spectrometry Center and contributes to medicinal chemistry research. His work includes teaching courses such as MEDCH 541 and engaging in research that spans various aspects of pharmacology and biochemistry. His research interests include DNA-m6A calling, long-read epigenetic and genetic analysis, and the development of fast and accurate DNA methylation calling methods. Whittington has contributed to studies on pharmacokinetics, drug tolerance, and the biochemical effects of pregnancy on amino acid levels, among other topics.

Research topics

• Geography
• Environmental science
• Water resource management
• Socioeconomics
• Environmental planning
• Archaeology
• Medicine
• History
• Economics
• Environmental health

Selected publications

• Collaborative management of the Grand Ethiopian Renaissance Dam increases economic benefits and resilience

  Nature Communications · 2021-09-23 · 95 citations

  articleOpen access

  The landscape of water infrastructure in the Nile Basin is changing with the construction of the Grand Ethiopian Renaissance Dam. Although this dam could improve electricity supply in Ethiopia and its neighbors, there is a lack of consensus between Ethiopia, Sudan, and Egypt on the dam operation. We introduce a new modeling framework that simulates the Nile River System and Egypt's macroeconomy, with dynamic feedbacks between the river system and the macroeconomy. Because the two systems "coevol…

  PublisherOA PDFDOI

• Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes

  Stem Cell Reports · 2021-09-09 · 81 citations

  articleOpen access

  Heart failure remains a significant cause of morbidity and mortality following myocardial infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell-derived cardiomyocytes is a promising preclinical therapy to restore function. Recent large animal data, however, have revealed a significant risk of engraftment arrhythmia (EA). Although transient, the risk posed by EA presents a barrier to clinical translation. We hypothesized that clinically approved antiarrhythmic…

  PublisherOA PDFDOI

• Investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry

  medRxiv · 2025-04-19 · 1 citations

  preprintOpen accessSenior authorCorresponding

  Abstract Most commercial passenger jet aircraft use compressed engine air after cooling as a source for ventilation and cabin pressurization onboard. This “bleed air” design means that engine oil and/or hydraulic fluid can contaminate the ventilation supply air during otherwise normal flights, exposing onboard crewmembers and passengers to the fumes. The oils and hydraulic fluids contain a complex mixture of triaryl phosphates (TAPs) and decomposition products. Although the health and flight saf…

  PublisherOA PDFDOI

• Breastfeeding on treprostinil: new data, lingering questions

  European Respiratory Journal · 2025-04-23

  letter

  <title>Extract</title> Pregnancy is a time of increased physiological stress that can be particularly dangerous for patients with pulmonary arterial hypertension (PAH), often necessitating parenteral prostacyclin therapy. [1] Despite the common use of treprostinil to control PAH during pregnancy and into the postpartum period, no human or animal data exist on its excretion into breastmilk. Outside of a single abstract, the safety of breastfeeding while on treprostinil is uncertain. [2] We report…

  PublisherDOI

• Contested baselines and transboundary water resources management, with illustrations from the Nile

  2025-08-12

  book-chapter1st authorCorresponding

  The effect of a policy intervention is estimated as the difference between a state of the world without the intervention – the dynamic baseline – and with the intervention. Negotiations on managing transboundary water resources confront three kinds of problems in specifying the dynamic baseline: unexamined baselines, uncertain baselines and contested baselines. This paper focuses on contested baselines. Controversy may arise from different ethical or political assessments of the appropriate choi…

  PublisherDOI

Frequent coauthors

• Marc Jeuland

  Duke University

  74 shared

• Xun Wu

  University of Hong Kong

  54 shared

• Evan D. Kharasch

  Duke University

  43 shared

• Christine Poulos

  RTI Health Solutions

  36 shared

• Joseph Cook

  31 shared

• Jashvant D. Unadkat

  University of Washington

  26 shared

• Kenneth E. Thummel

  University of Washington

  26 shared

• John D. Clemens

  International Centre for Diarrhoeal Disease Research

  24 shared

Education

• PhD, Business

  University of Texas at Austin

  1980

Similar researchers at University of Washington

• Allan Rettieh-78
• William Atkinsh-37
• Kimberly M. Alongeh-11