Dahlia M. Nielsen

Phenotype variability in diet-induced obesity and response to (−)-epigallocatechin gallate supplementation in a Diversity Outbred mouse cohort: A model for exploring gene x diet interactions for dietary bioactives

Nutrition Research · 2024 · 2 citations

Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure

Scientific Reports · 2025-01-02 · 1 citations

Cancers of the mesothelium, such as malignant mesothelioma (MM), historically have been attributed solely to exposure to asbestos. Recent large scale genetic and genomic functional studies now show that approximately 20% of all human mesotheliomas are causally linked to highly penetrant inherited (germline) pathogenic mutations in numerous cancer related genes. The rarity of these mutations in humans makes it difficult to perform statistically conclusive genetic studies to understand their biolo…

Assessing the effect of spaceflight stress on DNA sequence mutation using RNA-sequencing data

Gravitational and Space Research · 2025-01-01 · 1 citations

Abstract Understanding the effects of space radiation and microgravity on DNA is critical to assessing the impact of long-term spaceflight. While experiments performed in space constitute the most effective means of examining these effects, opportunities are limited and costly. As this bottleneck will likely continue for the foreseeable future, data from past experiments represent a particularly valuable source of information for continuing studies. To this end, NASA created GeneLab, a public Om…

Calling Environmentally Induced Mutations in a Highly Inbred Species using RNA-Sequencing Data

Zenodo (CERN European Organization for Nuclear Research) · 2022-11-11 · 1 citations

We present a pipeline to identify non-inherited variants from RNA-Sequencing data using software and custom scripts. We focus on the unique precautions to call variants in a highly inbred plant species. This pipeline uses data from highly inbred samples exposed to control and treatment conditions. This pipeline can be applied to investigate how stress conditions can cause mutations to accumulate over time.

Genetic variation in a plant-parasitic nematode is associated with gene expression changes conserved across evolutionarily distant host plants

bioRxiv (Cold Spring Harbor Laboratory) · 2026-01-12

ABSTRACT A hallmark of the interactions between endoparasites (parasites that live within plant tissue) and their hosts, is the parasites’ ability to hijack host gene expression to support their own existence. While a number of studies have been performed to identify plant genes that are recruited in this process, there is much that remains unknown. One mechanism by which these connections can be explored is using a traditional genetics approach – identifying connections between genetic variatio…