Charles M. Schroeder
University of Illinois Urbana-Champaign · Bioengineering
Active 1928–2026
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About
Charles M. Schroeder is a Professor and the Ray and Beverly Mentzer Faculty Scholar in Chemical and Biomolecular Engineering at the University of Illinois Urbana-Champaign. He is also an Affiliate in the Departments of Chemistry, Materials Science and Engineering, and Bioengineering, and a member of the Center for Biophysics and Computational Biology and the Institute for Genomic Biology in Biosystems Design. His research focuses on single molecule studies of polymer dynamics and biological systems, extending the field of single polymer dynamics to new materials. Professor Schroeder's work involves designing and implementing integrated microdevices for high-throughput screening of biomolecules for medical analysis, studying the action of natural and evolved enzymes at the molecular level, and investigating the non-equilibrium dynamics of soft materials. His research is highly interdisciplinary, bridging biology, engineering, and biotechnology, with applications in disease diagnosis, prediction of drug response, personalized medicine, and understanding biological mechanisms such as enzymatic reactions and viral infection pathways. He has been recognized with several awards, including the Camille Dreyfus Teacher-Scholar Award, NSF CAREER Award, Arthur B. Metzner Award from the Society of Rheology, and a Packard Fellowship in Science and Engineering. Since joining the department in 2008, Professor Schroeder has contributed extensively to research, education, and service in the…
Research topics
- Neuroscience
- Biology
- Computer Science
- Genetics
- Cognitive psychology
- Computational biology
- Psychology
- Evolutionary biology
Selected publications
Cross-species functional alignment reveals evolutionary hierarchy within the connectome
NeuroImage · 2020 · 270 citations
Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other spec…
Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling
Science · 2022-10-27 · 211 citations
articleGeneral conditions for organic reactions are important but rare, and efforts to identify them usually consider only narrow regions of chemical space. Discovering more general reaction conditions requires considering vast regions of chemical space derived from a large matrix of substrates crossed with a high-dimensional matrix of reaction conditions, rendering exhaustive experimentation impractical. Here, we report a simple closed-loop workflow that leverages data-guided matrix down-selection, un…
TALEN outperforms Cas9 in editing heterochromatin target sites
Nature Communications · 2021 · 96 citations
Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to directly study the behavior of CRISPR/Cas9 and TALEN. Our single-molecule imaging of genome-editing proteins reveals that Cas9 is less efficient in heterochromatin than TALEN because Cas9 becomes encumbe…
Closed-loop transfer enables artificial intelligence to yield chemical knowledge
Nature · 2024-08-28 · 63 citations
articleJournal of Neuroscience · 2020 · 61 citations
Watching the speaker can facilitate our understanding of what is being said. The mechanisms responsible for this influence of visual cues on the processing of speech remain incompletely understood. We studied these mechanisms by recording the electrical activity of the human brain through electrodes implanted surgically inside the brain. We found that visual inputs can operate by directly activating auditory cortical areas, and also indirectly by modulating the strength of cortical responses to…
Recent grants
NIH · $440k · 2017
NSF · $175k · 2016–2020
NIH · $5.1M · 2022
Frequent coauthors
- 139 shared
Péter Lakatos
Nathan Kline Institute for Psychiatric Research
- 54 shared
Ashesh D. Mehta
- 38 shared
Stephan Bickel
Feinstein Institute for Medical Research
- 36 shared
Nienke van Atteveldt
Vrije Universiteit Amsterdam
- 36 shared
Manuel Mercier
Inserm
- 36 shared
Songsong Li
University of Chicago
- 35 shared
Daniel C. Javitt
Columbia University Irving Medical Center
- 34 shared
Brian E. Russ
Icahn School of Medicine at Mount Sinai
Awards & honors
- Camille Dreyfus Teacher-Scholar Award
- NSF CAREER Award
- Arthur B. Metzner Award from the Society of Rheology
- Packard Fellowship in Science and Engineering
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