Chandra Sen

About

Chandra Sen, MD, is the co-director of the Anterior Skull Base Surgery Center and a member of the Lateral Skull Base Surgery Program at NYU Langone. He is a pioneer in anterior and lateral skull base surgery approaches and specializes in minimally invasive skull base surgery. Dr. Sen has been performing these procedures for almost 30 years and works with a team that has extensive experience treating tumors at the base of the skull, many of which are benign but located near critical nerves, blood vessels, and the brain stem. His focus is on surgical treatment of skull base tumors, employing specialized techniques and sometimes combining surgical and nonsurgical treatments to optimize patient outcomes. He emphasizes clear communication with patients to help them understand their conditions and treatment options, aiming to alleviate fears associated with brain tumor diagnoses. His research involves studying the anatomy of the skull base to better understand tumor behavior and improve surgical approaches, and he has published papers and written books on the topic. Dr. Sen is committed to advancing treatment outcomes and providing comprehensive, team-based care at NYU Langone, where he is recognized as one of America’s top doctors by Castle Connolly for over a decade.

Research topics

• Medicine
• Biology
• Pathology
• Internal medicine
• Bioinformatics
• Genetics
• Radiology
• Oncology

Selected publications

• Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated

  Journal of Clinical Oncology · 2021 · 134 citations

  PURPOSE: Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk of progression for individual patients is of pivotal importance. However, only biomarkers for highly aggressive tumors are established (CDKN2A/B and TERT), whereas no molecularly based stratification exists for the broad spectrum of patients with low- and intermediate-risk meningioma. METHODS: DNA methyla…

  DOI

• Cavernous sinus lesions

  Clinical Imaging · 2020 · 59 citations

  DOI

• Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing

  Neuro-Oncology Advances · 2023 · 33 citations

  Background: Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but the leading cause in pediatric patients and young adults. The variety and complexity of histologic subtypes can lead to diagnostic errors. DNA methylation is an epigenetic modification that provides a tumor type-specific signature that can be used for diagnosis. Methods: We performed a prospective study using DNA methylation analysis as a primary diagnostic method for 1921 brain…

  PublisherOA PDFDOI

• The effect of TERT promoter mutation on predicting meningioma outcomes: a multi-institutional cohort analysis

  The Lancet Oncology · 2025-09-01 · 11 citations

  articleOpen access
  PublisherOA PDFDOI

• DNA methylation profiling of pituitary neuroendocrine tumors identifies distinct clinical and pathological subtypes based on epigenetic differentiation

  Neuro-Oncology · 2025-04-28 · 8 citations

  articleOpen access

  BACKGROUND: Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neuroendocrine tumors. PitNETs can be challenging to classify, and current recommendations include a large immunohistochemical panel to differentiate among 14 WHO-recognized categories. METHODS: In this study, we analyzed clinical, immunohistochemical, and DNA methylation data of 118 PitNETs to develop a clinicomolecular approach to classifying PitNETs and identifying epigenetic classes. RESULTS: CNS DNA methy…

  PublisherOA PDFDOI

Frequent coauthors

• Laligam N. Sekhar

  Neurological Surgery

  179 shared

• Ivo P. Janecka

  82 shared

• Hugh D. Curtin

  Harvard University

  44 shared

• Spiros Pomonis

  University of Pittsburgh

  44 shared

• John G. Golfinos

  35 shared

• Giuseppe Lanzino

  Mayo Clinic in Arizona

  33 shared

• Donato Pacione

  NYU Langone Health

  31 shared

• William L. Hirsch

  29 shared

Awards & honors

• Named one of America’s top doctors by Castle Connolly for mo…

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