Douglas Kondziolka
· Gray Family Professor of Neurosurgery; Vice Chair, Clinical Research; Director, Gamma Knife ProgramNew York University · Neurosurgery
Active 1987–2026
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About
Douglas Kondziolka, MD, is a professor and vice chair of clinical research in the Department of Neurosurgery at NYU Langone Health, where he joined the faculty in 2012. He is also the director of the Center for Advanced Radiosurgery, where he treats patients with Gamma Knife radiosurgery and is recognized as the most experienced active neurosurgeon in this area worldwide. His clinical practice involves treating neurological conditions such as metastatic brain tumors, acoustic neuroma, meningioma, primary brain tumors, brain vascular malformations, movement and behavioral disorders, and trigeminal neuralgia. Prior to NYU Langone, he served as chief of stereotactic and functional neurosurgery and director of the Center for Brain Function and Behavior at the University of Pittsburgh, and worked with the Pittsburgh Penguins as their neurosurgeon from 2002 to 2012. Dr. Kondziolka's research spans many conditions, including benign and malignant tumors, vascular malformations, and functional disorders, with a focus on stereotactic radiosurgery. His work involves collecting patient outcomes and developing innovative artificial intelligence tools in medicine. He launched the world’s largest brain tumor dataset for research in 2022. His research also includes the informed consent process for surgery, neurostimulation for major depression, and clinical trials for stroke and neuroprogenitor cell implantation. He has published extensively, with 685 medical journal articles, 280 book…
Research topics
- Medicine
- Internal medicine
- Surgery
- Computer Science
- Radiology
- Oncology
- Psychology
- Artificial Intelligence
- Machine Learning
- Data science
Selected publications
Health system-scale language models are all-purpose prediction engines
Nature · 2023 · 432 citations
to train a large language model for medical language (NYUTron) and subsequently fine-tune it across a wide range of clinical and operational predictive tasks. We evaluated our approach within our health system for five such tasks: 30-day all-cause readmission prediction, in-hospital mortality prediction, comorbidity index prediction, length of stay prediction, and insurance denial prediction. We show that NYUTron has an area under the curve (AUC) of 78.7-94.9%, with an improvement of 5.36-14.7%…
JAMA Oncology · 2020 · 207 citations
Importance: Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care for patients with small cell lung cancer. Data on SRS are limited. Objective: To characterize and compare first-line SRS outcomes (without prior WBRT or prophylactic cranial irradiation) with those of first-line WBRT. Design, Setting, and Participants: FIRE-SCLC (First-line Radiosurgery for Small-Cell Lung Cancer)…
Stereotactic radiosurgery for pediatric brain arteriovenous malformations: long-term outcomes
Journal of Neurosurgery Pediatrics · 2020 · 25 citations
OBJECTIVE: Contrary to the better described obliteration- and hemorrhage-related data after stereotactic radiosurgery (SRS) of brain arteriovenous malformations (AVMs) in pediatric patients, estimates of the rarer complications, including cyst and tumor formation, are limited in the literature. The aim of the present study was to assess the long-term outcomes and risks of SRS for AVMs in pediatric patients (age < 18 years). METHODS: The authors retrospectively analyzed the International Radiosur…
Neurosurgery · 2022 · 17 citations
BACKGROUND: The optimal management of asymptomatic, presumed WHO grade I meningiomas remains controversial. OBJECTIVE: To define the safety and efficacy of stereotactic radiosurgery (SRS) compared with active surveillance for the management of patients with asymptomatic parafalcine/parasagittal (PFPS) meningiomas. METHODS: Data from SRS-treated patients from 14 centers and patients managed conservatively for an asymptomatic, PFPS meningioma were compared. Local tumor control rate and new neurolo…
Journal of Neurosurgery Pediatrics · 2020 · 15 citations
OBJECTIVE: Stereotactic radiosurgery (SRS) is a treatment option for pediatric brain arteriovenous malformations (AVMs), and early obliteration could encourage SRS utilization for a subset of particularly radiosensitive lesions. The objective of this study was to determine predictors of early obliteration after SRS for pediatric AVMs. METHODS: The authors performed a retrospective review of the International Radiosurgery Research Foundation AVM database. Obliterated pediatric AVMs were sorted in…
Recent grants
NIH · $440k · 1999
Frequent coauthors
- 2309 shared
L. Dade Lunsford
University of Pittsburgh Medical Center
- 1579 shared
John C. Flíckinger
University of Pittsburgh Medical Center
- 811 shared
Ajay Niranjan
University of Pittsburgh Medical Center
- 681 shared
Hideyuki Kano
- 582 shared
Jason P. Sheehan
University of Virginia Health System
- 415 shared
David Mathieu
Brown University
- 290 shared
Inga S. Grills
Beaumont Health
- 208 shared
Gene H. Barnett
Cleveland Clinic
Awards & honors
- Mahaley Clinical Award for brain tumor clinical research fro…
- Lars Leksell Award from the World Federation of Neurosurgica…
- Penfield Lecturer of the Canadian Neurosurgical Society
- Robert Florin Award from the American Association of Neurolo…
- Integra Foundation Award from the American Association of Ne…
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