Chaitan Khosla

About

Chaitan Khosla is a professor in the Department of Biochemistry at Stanford University. His research interests lie at the interface of chemistry and medicine, with a focus on the catalytic mechanisms of modular megasynthases such as polyketides synthases. His work aims to harness the programmable chemistry of these enzymes for the development of new antibiotics. More recently, his research has expanded to investigate the pathogenesis of celiac sprue, an autoimmune disease of the small intestine associated with HLA-DQ2. Professor Khosla has been recognized for his contributions to the enzymology of polyketide synthesis and Celiac Disease, including receiving the 2026 Abeles and Jencks Award for the Chemistry of Biological Processes.

Research topics

• Medicine
• Immunology
• Pathology
• Biology
• Computer Science
• Virology
• Internal medicine
• Business
• Bioinformatics
• Risk analysis (engineering)

Selected publications

• KIR ⁺ CD8 ⁺ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

  Science · 2022 · 238 citations

  T cells act specifically to suppress pathogenic T cells in autoimmune and infectious diseases.

  DOI

• IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

  Nature · 2020 · 229 citations

  DOI

• Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial

  Nature Communications · 2021 · 146 citations

  Type III interferons have been touted as promising therapeutics in outpatients with coronavirus disease 2019 (COVID-19). We conducted a randomized, single-blind, placebo-controlled trial (NCT04331899) in 120 outpatients with mild to moderate COVID-19 to determine whether a single, 180 mcg subcutaneous dose of Peginterferon Lambda-1a (Lambda) within 72 hours of diagnosis could shorten the duration of viral shedding (primary endpoint) or symptoms (secondary endpoint). In both the 60 patients recei…

  PublisherOA PDFDOI

• Prospects for Antibacterial Discovery and Development

  Journal of the American Chemical Society · 2021 · 90 citations

  Senior authorCorresponding

  The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only be countered through renewed investment in the discovery and development of antibiotics. There is no panacea for the antibacterial resistance crisis; instead, a multifaceted approach is called for. In this Perspective we make the case that, in the face of evolving clinical needs and enabling technologies, numerous validated antibacterial targets and associated lead molecules deserve a second look. At t…

  PublisherOA PDFDOI

• Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway

  Journal of the American Chemical Society · 2023-08-17 · 44 citations

  articleOpen accessSenior authorCorresponding

  Protein dysregulation has been characterized as the cause of pathogenesis in many different diseases. For proteins lacking easily druggable pockets or catalytically active sites, targeted protein degradation is an attractive therapeutic approach. While several methods for targeted protein degradation have been developed, there remains a demand for lower molecular weight molecules that promote efficient degradation of their targets. In this work, we describe the synthesis and validation of a seri…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R01GM067937

  NIH · $489k · 2006

• Mechanisms and Evolution of Assembly-Line Polyketide Synthases

  NIH · $2.4M · 2021–2026

• NIH Grant R21DK065965

  NIH · $290k · 2005

Frequent coauthors

• David E. Cane

  495 shared

• Alice Y. Chen

  69 shared

• Christopher T. Walsh

  Met Office

  62 shared

• John R. Jacobsen

  57 shared

• Rajesh S. Gokhale

  Indian Institute of Science Education and Research Pune

  55 shared

• Shiou‐Chuan Tsai

  University of California, Irvine

  53 shared

• Ludvig M. Sollid

  University of Oslo

  52 shared

• Chiara R. Valenzano

  50 shared

Labs

• Khosla LabPI

  Chemical Biology @ Stanford

Awards & honors

• 2026 Abeles and Jencks Award for the Chemistry of Biological…

Similar researchers at Stanford University

• Robert Baldwinh-115
• Arthur Kornbergh-114
• Paul Bergh-112