Carlo Bailey

Structural Components of Synaptic Plasticity and Memory Consolidation

Cold Spring Harbor Perspectives in Biology · 2015-07-01 · 405 citations

Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the mammalian hippocampus are associated with remodeling and growth of preexisting synapses and the formation of new synapses. Here, we compare and contrast structural components of the synaptic plasticity that underlies these two distinct forms of memory. In both cases, the structural changes involve time-dependent processes. Thus, some modifications are transient and may contribute to early formative stages of…

Common molecular mechanisms in explicit and implicit memory

Journal of Neurochemistry · 2006-06-01 · 214 citations

Cellular and molecular studies of both implicit and explicit memory suggest that experience-dependent modulation of synaptic strength and structure is a fundamental mechanism by which these memories are encoded and stored within the brain. In this review, we focus on recent advances in our understanding of two types of memory storage: (i) sensitization in Aplysia, a simple form of implicit memory, and (ii) formation of explicit spatial memories in the mouse hippocampus. These two processes share…

Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals

Proceedings of the National Academy of Sciences · 2008-06-26 · 153 citations

Neuroligin-1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. Despite evidence for the role of neuroligin-1 in specifying excitatory synapses, the underlying molecular mechanisms and physiological consequences that neuroligin-1 may have at mature synapses of normal adult animals remain unknown. By silencing endogenous neuroligin-1 acutely in the amygdala…

Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia

Neuron · 2008-09-01 · 151 citations

Chapter 10 Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia

Progress in brain research · 2008-01-01 · 131 citations