Jing Liu

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Nature · 2022 · 2693 citations

, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 pro…

The power of genetic diversity in genome-wide association studies of lipids

Nature · 2021 · 1032 citations

A saturated map of common genetic variants associated with human height

Nature · 2022 · 877 citations

) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than a…

The trans-ancestral genomic architecture of glycemic traits

Nature Genetics · 2021 · 877 citations

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Nature Genetics · 2022 · 724 citations