Breanna Howell
· Clinical Assistant ProfessorUniversity of Florida · Occupational Therapy
Active 1967–2025
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About
Dr. Breanna Howell, OTD, OTR/L, is a Clinical Assistant Professor at the Sensory Development Lab within the Department of Occupational Therapy at the University of Florida. She earned her Bachelor of Science in Health Science from Stetson University and completed both her Master of Arts in Occupational Therapy and Doctor of Occupational Therapy degrees at the University of Southern California. Dr. Howell has extensive clinical experience working with children who have a variety of conditions including autism spectrum disorder, genetic conditions, cerebral palsy, Down syndrome, anxiety, sensory processing differences, spina bifida, learning disabilities, and feeding difficulties. Her expertise encompasses sensory processing, feeding, constraint-induced movement therapy (CIMT), social skills and self-regulation, augmentative and alternative communication (AAC), the Therasuit method, and aquatic therapy. In her role at the Sensory Development Lab, Dr. Howell provides research interventions and supports the development of intervention studies, contributing to the lab's mission to advance understanding and treatment of sensory processing and related challenges in pediatric populations. Outside of her professional work, Dr. Howell enjoys spending time with her puppy, watching sunsets at the beach, and relaxing in her hammock.
Research topics
- Medicine
- Internal medicine
- Pharmacology
Selected publications
2024-01-01
articleOpen accessSenior author2024-01-01
articleOpen accessUNC Libraries · 2023-02-03
articleOpen accessInhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epithelium. Reduction in phospholipid excretion, as a consequence of MDR3 inhibition, decreases the formation of mixed micelles consisting of bile acids and phospholipids in the bile duct, resulting in a surplus of free bile acids that can damage the bile du…
Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury
UNC Libraries · 2020-11-02
articleOpen accessInhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid disposition within DILIsym®, a mechanistic model of DILI. In this paper, we use DILIsym® to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explo…
UNC Libraries · 2020-04-22
articleOpen accessTolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed with tolvaptan treatment in healthy subjects and in non-ADPKD indications, but ADPKD clinical trials showed evidence of drug-induced liver injury (DILI). Although all DILI events resolved, additional monitoring in tolvaptan-treated ADPKD patients is required. In vitro assays identif…
Recent grants
Frequent coauthors
- 88 shared
Scott Q. Siler
- 83 shared
Paul B. Watkins
GTx (United States)
- 55 shared
Yuching Yang
United States Food and Drug Administration
- 53 shared
Diane Longo
Simulations Plus (United States)
- 49 shared
A. Sangiovanni
- 45 shared
Jeffrey L. Woodhead
Simulations Plus (United States)
- 28 shared
Castro Valley
Sanofi (Mexico)
- 28 shared
Ers-Squibb Roche
Toray Industries, Inc. (Japan)
Labs
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