Blanche Capel
· James B. Duke Distinguished Professor of Cell BiologyDuke University · Cellular and Molecular Biology
Active 1979–2026
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About
Blanche Capel is the James B. Duke Distinguished Professor of Cell Biology at Duke University School of Medicine. She is also a Professor of Cell Biology, a member of the Duke Cancer Institute, and an affiliate of the Duke Regeneration Center. Her research focuses on cell and molecular biology, with involvement in programs such as the Program in Cell and Molecular Biology, Developmental & Stem Cell Biology Program, and the University Program in Genetics and Genomics. She is based at 307 Research Drive, Nanaline Bldg Room 452, Durham, NC 27710.
Research topics
- Biology
- Genetics
- Cell biology
- Molecular biology
- Biochemistry
- Chemistry
Selected publications
Temperature-dependent sex determination is mediated by pSTAT3 repression of <i>Kdm6b</i>
Science · 2020 · 152 citations
Senior authorCorresponding, a mediator of STAT3 phosphorylation, is elevated at the female temperature and acts as a temperature-sensitive regulator of STAT3 activation.
Biology of Reproduction · 2021 · 16 citations
Senior authorCorrespondingIn vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or mutation leads to severe PGC loss soon after specification or, in some species, germ cell transformation to somatic lineages. Our investigations into the role of DND1 in PGC specification and differentiation have been limited by the absence of an available antibody. To address this problem, we used CRISPR/Cas9 gen…
Scientific Data · 2024-04-13 · 12 citations
articleOpen accessThe rete ovarii (RO) is an epithelial structure that arises during development in close proximity to the ovary and persists throughout adulthood. However, the functional significance of the RO remains elusive, and it is absent from recent discussions of female reproductive anatomy. The RO comprises three regions: the intraovarian rete within the ovary, the extraovarian rete in the periovarian tissue, and the connecting rete linking the two. We hypothesize that the RO plays a pivotal role in ovar…
Current Biology · 2023-06-24 · 9 citations
articleSenior authorCorrespondingBiology of Reproduction · 2025-04-03 · 7 citations
articleOpen accessSenior authorTypically, DNA-damaging chemotherapy (CTx) regimens have a gonadotoxic effect and cause premature ovarian insufficiency (POI), characterized by infertility and estrogen deficiency. However, whether loss of granulosa cells killed directly by CTx contributes significantly to POI has not been determined. To address this issue, we used a previously established mouse model of CTx-induced POI. The alkylating drugs Busulfan (8.75 mg/kg) and Cyclophosphamide (100 mg/kg) were administered to 8-week-old F…
Recent grants
NSF · $900k · 2019–2024
NIH · $1.7M · 2008
NIH · $527k · 2000
Frequent coauthors
- 86 shared
Jennifer McKey
University of Colorado Anschutz Medical Campus
- 83 shared
Tony DeFalco
Cincinnati Children's Hospital Medical Center
- 81 shared
Corey Bunce
- 66 shared
Danielle M. Maatouk
- 56 shared
Jonah Cool
Chan Zuckerberg Initiative (United States)
- 55 shared
Humphrey Hung‐Chang Yao
National Institute of Environmental Health Sciences
- 55 shared
Lindsey Mork
University of Southern California
- 53 shared
Leo DiNapoli
Duke University
Education
- 1989
Ph.D., Genetics
University of Pennsylvania
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