Staci D. Bilbo

About

Staci D. Bilbo is the Haley Family Professor of Psychology and Neuroscience at Duke University School of Medicine. She serves as the Interim Chair of the Department of Neurobiology and holds multiple titles including Professor of Psychology and Neuroscience, Professor of Neurobiology, Professor in Cell Biology, and Professor in Integrative Immunobiology. She is a faculty network member of the Duke Institute for Brain Sciences. Her research focuses on the fields of psychology, neuroscience, neurobiology, cell biology, and immunobiology, contributing to the understanding of brain and immune system interactions.

Research topics

• Biology
• Internal medicine
• Medicine
• Immunology
• Computer Science
• Sociology
• Psychology
• Neuroscience
• Physiology
• Genetics

Selected publications

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · 1828 citations

  PublisherOA PDFDOI

• Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

  Science Translational Medicine · 2021 · 138 citations

  There is a persistent bias toward higher prevalence and increased severity of coronavirus disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex difference remain incompletely understood. Interferon responses have been implicated as a modulator of COVID-19 disease in adults and play a key role in the placental antiviral response. Moreover, the interferon response has been shown to alter Fc receptor expression and therefore may affect placental antibody transfer. Here, we…

  DOI

• Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

  Cell Reports · 2022 · 102 citations

  Senior authorCorresponding

  Gestational exposure to environmental toxins and socioeconomic stressors is epidemiologically linked to neurodevelopmental disorders with strong male bias, such as autism. We model these prenatal risk factors in mice by co-exposing pregnant dams to an environmental pollutant and limited-resource stress, which robustly activates the maternal immune system. Only male offspring display long-lasting behavioral abnormalities and alterations in the activity of brain networks encoding social interactio…

  DOI

• Maternal diet disrupts the placenta–brain axis in a sex-specific manner

  Nature Metabolism · 2022 · 89 citations

  Senior authorCorresponding
  PublisherOA PDFDOI

• Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity

  Cell Reports · 2024-06-01 · 26 citations

  articleOpen access

  Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain microglial programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between fetal brain macrophages (microglia) and fetal placental macrophages (Hofbauer cells) in a mouse model of…

  PublisherOA PDFDOI

Recent grants

• Sex Differences in Developing Microglia: Implications for Synaptic Pruning

  NIH · $2.0M · 2016–2018

• NIH Grant R01DA025978

  NIH · $1.0M · 2013

• NIH Grant F32MH076320

  NIH · $95k · 2008

Frequent coauthors

• J-Y Sung

  Kyung Hee University

  242 shared

• Steven Swanson

  Brigham and Women's Hospital

  242 shared

• Kyung‐Min Kim

  Kyungpook National University

  242 shared

• L Wong

  Kyung Hee University

  242 shared

• Jong Min Lee

  Seoul St. Mary's Hospital

  242 shared

• Aditi Hazra

  Harvard University

  242 shared

• Laura C. Collins

  Hadassah Medical Center

  242 shared

• Virginia A. LiVolsi

  Hospital of the University of Pennsylvania

  242 shared

Similar researchers at Duke University

• Blanche Capelh-107
• Christopher M. Counterh-74
• Vadim Y Arshavskyh-72