Beverly Errede

About

Beverly Errede is an Emeritus Professor of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill. She holds a PhD from the University of California, San Diego. Her professional role is associated with the Department of Biochemistry and Biophysics, located at 120 Mason Farm Road, Chapel Hill, NC. The page provides her contact information, including an office phone number and email address, but does not include specific details about her research focus, background, or key contributions.

Research topics

• Cell biology
• Biology
• Genetics
• Biological system
• Computational biology
• Physics
• Biophysics
• Optoelectronics

Selected publications

• An improved short‐lived fluorescent protein transcriptional reporter for <i>Saccharomyces cerevisiae</i>

  Yeast · 2012-10-09 · 59 citations

  articleSenior authorCorresponding

  Ideal reporter genes for temporal transcription programmes have short half-lives that restrict their detection to the window in which their transcripts are present and translated. In an effort to meet this criterion for reporters of transcription in individual living cells, we adapted the ubiquitin fusion strategy for programmable N-end rule degradation to generate an N-degron version of green fluorescent protein (GFP) with a half-life of ~7 min. The GFP variant we used here (designated GFP*) ha…

  PublisherDOI

• Yeast Dynamically Modify Their Environment to Achieve Better Mating Efficiency

  Science Signaling · 2011-08-16 · 55 citations

  articleCorresponding

  The maintenance and detection of signaling gradients are critical for proper development and cell migration. In single-cell organisms, gradient detection allows cells to orient toward a distant mating partner or nutrient source. Budding yeast expand their growth toward mating pheromone gradients through a process known as chemotropic growth. MATα cells secrete α-factor pheromone that stimulates chemotropism and mating differentiation in MATa cells and vice versa. Paradoxically, MATa cells secret…

  PublisherDOI

• Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα

  Molecular Biology of the Cell · 2015-07-16 · 20 citations

  article1st authorCorresponding

  Mitogen-activated protein kinase (MAPK) pathways control many cellular processes, including differentiation and proliferation. These pathways commonly activate MAPK isoforms that have redundant or overlapping function. However, recent studies have revealed circumstances in which MAPK isoforms have specialized, nonoverlapping roles in differentiation. The mechanisms that underlie this specialization are not well understood. To address this question, we sought to establish regulatory mechanisms th…

  PublisherDOI

• Combined computational and experimental analysis reveals mitogen-activated protein kinase–mediated feedback phosphorylation as a mechanism for signaling specificity

  Molecular Biology of the Cell · 2012-08-09 · 19 citations

  article

  Different environmental stimuli often use the same set of signaling proteins to achieve very different physiological outcomes. The mating and invasive growth pathways in yeast each employ a mitogen-activated protein (MAP) kinase cascade that includes Ste20, Ste11, and Ste7. Whereas proper mating requires Ste7 activation of the MAP kinase Fus3, invasive growth requires activation of the alternate MAP kinase Kss1. To determine how MAP kinase specificity is achieved, we used a series of mathematica…

  PublisherDOI

• Positive roles for negative regulators in the mating response of yeast

  Molecular Systems Biology · 2012-01-01 · 16 citations

  articleOpen access

  All cells must detect and respond to changes in their environment, often through changes in gene expression. The yeast pheromone pathway has been extensively characterized, and is an ideal system for studying transcriptional regulation. Here we combine computational and experimental approaches to study transcriptional regulation mediated by Ste12, the key transcription factor in the pheromone response. Our mathematical model is able to explain multiple counterintuitive experimental results and l…

  PublisherDOI

Recent grants

• NIH Grant R01GM030619

  NIH · $1.3M · 1994

• NIH Grant R01GM079271

  NIH · $4.0M · 2019

• Mechanisms of noise regulation in cell fate transitions

  NIH · $2.1M · 2015–2019

Frequent coauthors

• Timothy C. Elston

  University of North Carolina at Chapel Hill

  23 shared

• Henrik Dohlman

  17 shared

• M Company

  17 shared

• R. Keith Esch

  University of Hagen

  11 shared

• Malcolm Whiteway

  Concordia University

  9 shared

• Melinda Baur

  9 shared

• Siarhei Hladyshau

  Georgia Institute of Technology

  7 shared

• Denis Tsygankov

  Georgia Institute of Technology

  7 shared

Labs

• Beverly Errede LabPI

Education

• Ph.D.

  University of California, San Diego

Similar researchers at University of North Carolina at Chapel Hill

• Michael Rubinsteinh-90
• Ronald Swanstromh-83
• William Marzluffh-78