Barbara Jung

· MD

University of California, San Diego · Gastroenterology

Active 1998–2026

h-index41

Citations4.8k

Papers15921 last 5y

Funding$3.7M

Academic metrics are sourced from OpenAlex and public funding records; values may differ from Google Scholar.

Faculty page

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Research topics

Cell biology
Cancer research
Biology
Biochemistry
Chemistry
Internal medicine
Medicine
Genetics

Selected publications

Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner
Scientific Reports · 2025-03-12 · 3 citations
articleOpen accessSenior authorCorresponding
Advanced colorectal cancer (CRC) continues to present with poor survival and treatment options remain limited. We have shown that increased activin A (activin) expression in the tumor microenvironment (TME) is associated with poor outcome in a cohort of stage III and IV CRC patients. Here, we hypothesized that activin promotes stage specific outcomes in CRC, enhancing metastasis and tolerance in late-stage CRC exclusively. We employed Digital Spatial Profiling (DSP) technology on a cohort of sta…
Publisher OA PDF DOI
Abstract 5000: Activin receptor subtype-2A regulates innate immune cell activation and non-canonical signaling in pancreatic cancer cells
Cancer Research · 2026-04-03
articleSenior author
Abstract More than 50% of all pancreatic cancer patients present with distant metastasis at the time of diagnosis highlighting the need for early biomarkers of pancreatic cancer progression. Inflammatory disorders of the pancreas increases the risk for developing pancreatic cancer suggesting an inflammatory component to disease initiation. Our research team has previously shown that activin A (activin), a critical inflammatory cytokine, contributes to pancreatitis development through activation…
Publisher DOI
Abstract 4992: Activin A promotes PDAC progression via immunosuppression and non-canonical signaling
Cancer Research · 2026-04-03
articleSenior author
Abstract The five-year survival rate for pancreatic cancer patients remains at 13%. More than 90% of these patients are diagnosed with pancreatic ductal adenocarcinoma (PDAC). Acute pancreatitis and chronic pancreatitis are risk factors for developing PDAC suggesting a strong inflammatory role for disease initiation. Recently, we found that activin a (activin), a TGFβ superfamily member, drives inflammation in acute pancreatitis via recruitment of macrophages and activation of neutrophils. In ke…
Publisher DOI
Tu1411: ACTIVIN A IS ASSOCIATED WITH A REDUCTION IN STROMAL ACTIVITY, MEMORY T-CELL AND MACROPHAGE RECRUITMENT IN PDAC
Gastroenterology · 2025-05-01
articleSenior author
Publisher DOI
Su1444 ACTIVIN A SIGNALING STIMULATES INNATE IMMUNE CELL ACTIVATION IN PANCREATITIS
Gastroenterology · 2024-05-01
articleSenior author
Publisher DOI

Recent grants

Mechanism of colon cancer metastasis: combined role of activin and TGF-beta signaling
NIH · $3.0M · 2010–2023
NIH Grant K08DK074019
NIH · $609k · 2010

Frequent coauthors

John M. Carethers
54 shared
Jessica Bauer
University of Washington
50 shared
Paolo Bianchi
IRCCS Humanitas Research Hospital
37 shared
Alberto Malesci
Vita-Salute San Raffaele University
37 shared
Luigi Laghi
University of Parma
37 shared
Maurizio Ponz de Leòn
36 shared
Giuseppe Celesti
36 shared
Gabriele Delconte
36 shared

Labs

Barbara JungPI

Education

Ph.D., Biology
University of California, San Diego
1992
B.S., Biology
University of California, San Diego
1987

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