About

Alison Axtman is associated with the SGC-UNC, an open science chemical biology lab that aims to illuminate the dark proteins of the human genome through the generation and distribution of chemical tools and reagents to the scientific community. The lab operates as the US site of the Structural Genomics Consortium and embraces an open science policy, including a 'no patent' policy and the immediate sharing of research data and reagents without restrictions. The lab's philosophy emphasizes collaboration, transparency, and the collective effort to advance understanding of human proteins, with a focus on drug discovery, chemical biology, and medicinal chemistry. The lab's goals include illuminating dark proteins, fulfilling team members’ career advancement goals, contributing to the organizational objectives of the SGC, and supporting the scientific community through open sharing of data and reagents. Mentoring is a key component, with a focus on training students and post-docs for successful careers in academia, industry, or other fields. The lab promotes a culture of safety, respect, and active participation in lab responsibilities, seminars, conferences, and open science practices. The environment encourages flexible work hours, regular communication, and active engagement in scientific dissemination, including conference attendance and authorship, following established guidelines. Overall, Alison Axtman's role involves fostering a collaborative, open, and productive research environment dedicated to advancing chemical biology and human genome research.

Research topics

• Cell biology
• Biology
• Computational biology
• Computer Science
• Chemistry

Selected publications

• Development of a potent and selective chemical probe for the pleiotropic kinase CK2

  Cell chemical biology · 2021 · 111 citations

  Senior authorCorresponding
  • Cell biology
  • Chemistry
  • Biology
  DOI

• The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

  International Journal of Molecular Sciences · 2021 · 110 citations

  • Computer Science
  • Computational biology
  • Computer Science

  We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.

  DOI

Recent grants

• TREAT AD Structural Biology Core

  NIH · $47.5M · 2019–2029

Frequent coauthors

• Carrow I. Wells

  University of North Carolina at Chapel Hill

  62 shared

• David H. Drewry

  University of North Carolina at Chapel Hill

  60 shared

• Timothy M. Willson

  45 shared

• O. Gileadi

  University of Oxford

  35 shared

• Jeffery L. Smith

  University of North Carolina at Chapel Hill

  28 shared

• William J. Zuercher

  27 shared

• Jonathan M. Elkins

  Universidade Estadual de Campinas (UNICAMP)

  25 shared

• Julie E. Pickett

  National Institute of Mental Health

  24 shared

Labs

• SGC-UNCPI

Education

• CMAD Postdoctoral Fellow, Chemistry

  Stanford University

  2014

• Ph.D., Medicinal Chemistry

  University of Kansas

  2011

• M.S., Medicinal Chemistry

  University of Kansas

  2009

• B.A., Spanish

  Case Western Reserve University

  2006

• B.S., Chemistry

  Case Western Reserve University

  2006

Awards & honors

• Named one of the world’s 400 most influential biomedical res…

Similar researchers at University of North Carolina at Chapel Hill

• Barry M. Popkinh-170
• Cynthia Bulikh-134
• Doug Perkinsh-115
• Paul Watkinsh-107
• Linda Adairh-106