Alexander Angerhofer

About

Alexander Angerhofer is a professor in the Department of Chemistry at the University of Florida. His research focuses on the application of electron paramagnetic resonance to study metalloenzymes, specifically investigating the catalytic mechanisms of the manganese-containing enzyme oxalate decarboxylase. His work aims to elucidate the role of the enzyme’s quaternary structure and employs spectroscopic and structural methods, including site-directed mutagenesis with unnatural amino acids, to understand long-range electron transfer between manganese ions within the enzyme. Additionally, he utilizes chemical, molecular biology, and bioinformatics tools to enhance enzyme performance at physiological pH for applications in medicine and food science. Angerhofer has a distinguished academic background, including a Ph.D. in Physics from Universität Stuttgart, a postdoctoral fellowship at Argonne National Laboratory, and habilitation from Universität Stuttgart. His contributions to the field have been recognized with awards such as the NSF in 2020, and he has served as Associate Chair of the Department of Chemistry at the University of Florida.

Research topics

• Crystallography
• Chemistry
• Physics
• Nanotechnology
• Materials science
• Engineering
• Atomic physics
• Photochemistry
• Quantum mechanics
• Inorganic chemistry

Selected publications

• Manipulating Atomic Structures at the Au/TiO₂ Interface for O₂ Activation

  Journal of the American Chemical Society · 2020 · 130 citations

  activation. Collectively, our results establish an atomic-level description of the underlying mechanism regulating metal/oxide interfaces for the optimization of heterogeneous catalysis.

  PublisherDOI

• Expansion of the Family of Molecular Nanoparticles of Cerium Dioxide and Their Catalytic Scavenging of Hydroxyl Radicals

  Inorganic Chemistry · 2021 · 41 citations

  The syntheses, crystal structures, and catalytic radical scavenging activity are reported for four new molecular clusters that have resulted from a bottom-up molecular approach to nanoscale CeO2. They are [Ce6O4(OH)4(dmb)12(H2O)4] (dmb– = 2,6-dimethoxybenzoate), [Ce16O17(OH)6(O2CPh)24(HO2CPh)4], [Ce19O18(OH)9(O2CPh)27(H2O)(py)3], and [Ce24O27(OH)9(O2CPh)30(py)4]. They represent a major expansion of our family of so-called “molecular nanoparticles” of this metal oxide to seven members, and their…

  PublisherDOI

• The absence of the queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in <i>Escherichia coli</i> K12

  Metallomics · 2022-01-01 · 33 citations

  articleOpen access

  Queuosine (Q) is a conserved hypermodification of the wobble base of tRNA containing GUN anticodons but the physiological consequences of Q deficiency are poorly understood in bacteria. This work combines transcriptomic, proteomic and physiological studies to characterize a Q-deficient Escherichia coli K12 MG1655 mutant. The absence of Q led to an increased resistance to nickel and cobalt, and to an increased sensitivity to cadmium, compared to the wild-type (WT) strain. Transcriptomic analysis…

  PublisherOA PDFDOI

• Elucidating the Origin of Plasmon-Generated Hot Holes in Water Oxidation

  ACS Nano · 2023-04-13 · 31 citations

  article

  Plasmon-generated hot electrons in metal/oxide heterostructures have been used extensively for driving photochemistry. However, little is known about the origin of plasmon-generated hot holes in promoting photochemical reactions. Herein, we discover that, during the nonradiative plasmon decay, the interband excitation rather than the intraband excitation generates energetic hot holes that enable to drive the water oxidation at the Au/TiO2 interface. Distinct from lukewarm holes via the intraband…

  PublisherDOI

• Coaxially Conductive Organic Wires Through Self-Assembly

  Journal of the American Chemical Society · 2023-02-28 · 23 citations

  article

  Here, we describe the synthesis of the hexameric macrocyclic aniline (MA[6]), which spontaneously assembles into coaxially conductive organic wires in its oxidized and acidified emeraldine salt (ES) form. Electrical measurements reveal that ES-MA[6] exhibits high electrical conductivity (7.5 × 10–2 S·cm–1) and that this conductivity is acid–base responsive. Single-crystal X-ray crystallography reveals that ES-MA[6] assembles into well-defined trimeric units that then stack into nanotubes with re…

  PublisherDOI

Recent grants

• Enzymatic Mechanism of Oxalate Decarboxylase Revealed by Biophysical and Structural Studies

  NSF · $473k · 2020–2024

• The Catalytic Mechanism of Oxalate Decarboxylase Studied by Advanced EPR Experiments

  NSF · $476k · 2008–2012

• The Catalytic Mechanism of Oxalate Decarboxylase Studied by Advanced EPR Techniques

  NSF · $430k · 2012–2016

Frequent coauthors

• Peter J. Bratt

  78 shared

• Louis‐Claude Brunel

  70 shared

• J. Krzystek

  National High Magnetic Field Laboratory

  45 shared

• Martin Rohrer

  Bayer (Germany)

  41 shared

• Gail E. Fanucci

  University of Florida

  38 shared

• Christopher P. Jaroniec

  The Ohio State University

  36 shared

• Karen A. Hyde

  Université Claude Bernard Lyon 1

  36 shared

• Gary J. Gerfen

  Albert Einstein College of Medicine

  36 shared

Awards & honors

• NSF (2020)

Similar researchers at University of Florida

• George Christouh-133
• Rodney J. Bartletth-118
• Alberto Perezh-59