Christopher Jaroniec

About

Christopher Jaroniec is Arts and Sciences Distinguished Professor and Associate Dean for Research and Creative Inquiry in the College of Arts and Sciences at The Ohio State University. He received his B.S. in Chemistry from Kent State University in 1997 and his Ph.D. in Physical Chemistry from the Massachusetts Institute of Technology in 2003, where he was a National Science Foundation Graduate Research Fellow. He also completed postdoctoral research as a Damon Runyon Cancer Research Foundation Fellow at the National Institutes of Health. Jaroniec joined Ohio State as an Assistant Professor in 2006, was promoted to Associate Professor in 2011, and to Professor in 2014. He was named Evans Scholar in 2013 and College of Arts and Sciences Distinguished Professor in 2021. Currently, he also serves as Associate Director of the OSU CCIC NMR Facility, directing operations of high-field solid-state NMR instruments. His research focuses on developing multidimensional magic-angle spinning solid-state NMR techniques and applying them to analyze molecular structure, conformational dynamics, and intermolecular interactions of biological macromolecules relevant to human health. His work employs complementary biophysical, computational, biochemical, and molecular biology methods, including solution-state NMR and cryo-electron microscopy. Jaroniec has received numerous national and international awards, including the NSF CAREER Award, Eli Lilly Young Investigator Award, Camille Dreyfus…

Research topics

• Chemistry
• Crystallography
• Nuclear magnetic resonance
• Biophysics
• Materials science

Selected publications

• Sensitivity boosts by the CPMAS CryoProbe for challenging biological assemblies

  Journal of Magnetic Resonance · 2019-12-23 · 81 citations

  articleOpen access
  PublisherOA PDFDOI

• Histone H4 Tails in Nucleosomes: a Fuzzy Interaction with DNA

  Angewandte Chemie International Edition · 2021-02-01 · 40 citations

  articleOpen accessSenior authorCorresponding

  Abstract The interaction of positively charged N‐terminal histone tails with nucleosomal DNA plays an important role in chromatin assembly and regulation, modulating their susceptibility to post‐translational modifications and recognition by chromatin‐binding proteins. Here, we report residue‐specific 15 N NMR relaxation rates for histone H4 tails in reconstituted nucleosomes. These data indicate that H4 tails are strongly dynamically disordered, albeit with reduced conformational flexibility co…

  PublisherOA PDFDOI

• Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy

  Proceedings of the National Academy of Sciences · 2022-07-20 · 33 citations

  articleOpen accessSenior author

  The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick geometry. However, they can also adopt alternate Hoogsteen conformations in various complexes of DNA with proteins and small molecules, which are key for biological function and mechanism. While detection of Hoogsteen base pairs in large DNA complexes and assemblies poses considerable challenges for traditional structural biology techniques, we show here that multidimensional dynamic nuclear polarization-enhanc…

  PublisherOA PDFDOI

• Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR

  Journal of Magnetic Resonance · 2019-07-09 · 31 citations

  reviewOpen access1st authorCorresponding
  PublisherOA PDFDOI

• Conformational Dynamics of Histone H3 Tails in Chromatin

  The Journal of Physical Chemistry Letters · 2021-06-29 · 25 citations

  articleOpen accessSenior authorCorresponding

  Chromatin is a supramolecular DNA–protein complex that compacts eukaryotic genomes and regulates their accessibility and functions. Dynamically disordered histone H3 N-terminal tails are among key chromatin regulatory components. Here, we used high-resolution-magic-angle-spinning NMR measurements of backbone amide 15N spin relaxation rates to investigate, with residue-specific detail, the dynamics and interactions of H3 tails in recombinant 13C,15N-enriched nucleosome arrays containing 15, 30, o…

  PublisherOA PDFDOI

Recent grants

• Molecular Mechanisms of Prion and Amyloid Propagation

  NIH · $3.2M · 2011–2024

• Structural Studies of Proteins by Paramagnetic Solid-State NMR Spectroscopy

  NSF · $932k · 2023–2027

• NIH Grant S10OD012303

  NIH · $2.0M · 2016

Frequent coauthors

• Robert G. Griffin

  Massachusetts Institute of Technology

  53 shared

• Glenn L. Millhauser

  University of California, Santa Cruz

  36 shared

• Alexander Angerhofer

  University of Florida

  36 shared

• Christoph Boehme

  University of Utah

  36 shared

• Gary J. Gerfen

  Albert Einstein College of Medicine

  36 shared

• Guido Pintacuda

  École Normale Supérieure de Lyon

  36 shared

• Martin L. Kirk

  The Ohio State University

  36 shared

• Michael Bowman

  Iowa State University

  36 shared

Awards & honors

• CAREER Award from the National Science Foundation
• Eli Lilly Young Investigator Award in Analytical Chemistry
• Camille Dreyfus Teacher-Scholar Award
• Founders' Medal from the International Council on Magnetic R…
• Varian Young Investigator Award in Magnetic Resonance

Similar researchers at Ohio State University

• Yiying Wuh-70
• Patrick Woodwardh-69
• Claudia Turroh-64