About

Aaron Dingle, PhD, is an Assistant Professor in the Division of Plastic Surgery at the University of Wisconsin School of Medicine and Public Health. He earned his PhD from the Bernard O'Brien Institute of Microsurgery at the University of Melbourne, Melbourne, Australia. Dr. Dingle is an accomplished scientist specializing in tissue engineering and regenerative medicine, with research focused on restoring form and function through tissue preservation, regeneration, and replacement, particularly involving nerve, muscle, and bone tissues. His work encompasses reconstructive surgery and the biological mechanisms of disease and regeneration, including the impacts of ischemia–reperfusion injury on tissue survival and repair. Through his research, Dr. Dingle aims to develop innovative therapies that enhance recovery and improve quality of life for patients with complex injuries.

Research topics

• Computer Science
• Medicine
• Biology
• Biomedical engineering
• Internal medicine
• Anatomy
• Neuroscience
• Pathology
• Chemistry
• Intensive care medicine
• Computer hardware
• Mathematics
• Cell biology
• Materials science
• Endocrinology
• Cancer research

Selected publications

• Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications

  Frontiers in Bioengineering and Biotechnology · 2022 · 44 citations

  • Computer Science
  • Medicine
  • Biomedical engineering

  and small animal studies are successful in inducing osteogenesis with all electrical stimulation modalities: direct current, pulsed electromagnetic field, and capacitive coupling. However, large animal studies are largely unsuccessful with the non-invasive modalities. This may be due to issues of scale and thickness of tissue planes with varying levels of resistivity, not present in small animal models. Additionally, it is difficult to draw conclusions from studies due to the varying units of stimulation strength and stimulation protocols and incomplete device specification reporting. To better understand the disconnect between the large and small animal model, the authors recommend increasing scientific rigor for these studies and reporting a novel minimum set of parameters depending on the stimulation modality.

  DOI

• Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation

  Journal of Neural Engineering · 2020 · 112 citations

  • Anatomy
  • Medicine
  • Neuroscience

  OBJECTIVE: Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly few studies characterizing the anatomy of the vagus nerve in large animal models as it pertains to on-and off-target engagement of local fibers. We sought to address this gap by evaluating vagal anatomy in the pig, whose vagus nerve organization and size approximates the human vagus nerve. APPROACH: Here we combined microdissection, histology, and immunohistochemistry to provide data on key features across the cervical vagus nerve in a swine model, and compare our results to other animal models (mouse, rat, dog, non-human primate) and humans. MAIN RESULTS: In a swine model we quantified the nerve diameter, number and diameter of fascicles, and distance of fascicles from the epineural surface where stimulating electrodes are placed. We also characterized the relative locations of the superior and recurrent laryngeal branches of the vagus nerve that have been implicated in therapy limiting side effects with common electrode placement. We identified key variants across the cohort that may be important for VNS with respect to changing sympathetic/parasympathetic tone, such as cross-connections to the sympathetic trunk. We discovered that cell bodies of pseudo-unipolar cells aggregate together to form a very distinct grouping within the nodose ganglion. This distinct grouping gives rise to a larger number of smaller fascicles as one moves caudally down the vagus nerve. This often leads to a distinct bimodal organization, or 'vagotopy'. This vagotopy was supported by immunohistochemistry where approximately half of the fascicles were immunoreactive for choline acetyltransferase, and reactive fascicles were generally grouped in one half of the nerve. SIGNIFICANCE: The vagotopy observed via histology may be advantageous to exploit in design of electrodes/stimulation paradigms. We also placed our data in context of historic and recent histology spanning multiple models, thus providing a comprehensive resource to understand similarities and differences across species.

  PublisherDOI

• Cuff and sieve electrode (CASE): The combination of neural electrodes for bi-directional peripheral nerve interfacing

  Journal of Neuroscience Methods · 2020 · 18 citations

  • Computer Science
  • Neuroscience
  • Biomedical engineering
  DOI

• Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids

  Biomaterials · 2020 · 54 citations

  • Biology
  • Cell biology
  • Pathology
  DOI

Frequent coauthors

• Samuel O. Poore

  University of Wisconsin–Madison

  62 shared

• Weifeng Zeng

  University of Wisconsin–Madison

  51 shared

• Geraldine M. Mitchell

  St Vincents Institute of Medical Research

  49 shared

• Caroline J. Taylor

  La Trobe University

  29 shared

• Aaron J. Suminski

  University of Wisconsin–Madison

  29 shared

• Justin C. Williams

  29 shared

• Wayne A. Morrison

  St Vincents Institute of Medical Research

  26 shared

• Peter J. Nicksic

  University of Wisconsin–Madison

  26 shared

Labs

• Dingle LabPI

Similar researchers at University of Wisconsin-Madison

• John Ralphh-178
• Brad Astorh-119
• Weibo Caih-113
• Matt Turnerh-113
• Paul Ahlquisth-110