The impact of cancer diagnosis on functional decline in adults aged 50 and older: the US Health and Retirement Study

Journal of Cancer Survivorship · 2025-07-29 · 2 citations

PURPOSE: We conducted a longitudinal secondary data analysis to estimate long-term functional limitation trajectories of adults over 50 with cancer compared to cancer-free individuals. METHODS: Using the Health and Retirement Study (1998-2020), we followed adults over 50 without cancer history. Incident cancer was self-reported or proxy reported. Functional decline was assessed using self-reported independence in six domains, including instrumental activities of daily living (IADL), activities of daily living (ADL), mobility, large muscle, gross motor, and fine motor skills. We employed linear probability models with repeated measures to estimate independence probabilities. RESULTS: Among 15,972 participants (mean [SD] age, 66.1 [9.9] years), 23.1% reported cancer during follow-up. Before diagnosis, individuals with cancer had a 1.3% lower probability of IADL independence compared to cancer-free individuals (95% CI = - 1.9, - 0.7). After diagnosis, cancer survivors experienced a sharp 6% drop in IADL independence, resulting in a 3.4% lower probability than in those without cancer (- 4.6, - 2.2). The annual rate of IADL decline after diagnosis was slower in cancer survivors compared to those without cancer (- 0.9% vs. - 1.3%). Similar patterns were observed for ADL. The greatest immediate reduction was in the gross motor domain with a decline of 8.6% (- 10.4, - 6.8). CONCLUSIONS: Cancer survivors experienced rapid functional decline at diagnosis, possibly attributed to active treatment. Following diagnosis, cancer survivors had a more gradual loss in functional independence compared to cancer-free individuals. IMPLICATIONS FOR CANCER SURVIVORS: Findings underscore the importance of proactive, tailored interventions to support functional independence in older cancer survivors, particularly around diagnosis.

Table S6 from The Risk of Type 2 Diabetes among Older Asian, Native Hawaiian, and Pacific Islander Colorectal Cancer Survivors: A Population-Based Study Using the SEER–Medicare Database

2025-06-03

<p>This table summarizes the hazard ratios and corresponding 95% CIs for various risk factors for Type 2 Diabetes.</p>

Molecular engineering of sterically-isolated spherical chromophores for high-performance second order nonlinear optical polymers

Dyes and Pigments · 2025-07-03

Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project

European Journal of Nutrition · 2025-08-31

PURPOSE: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. METHODS: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. RESULTS: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. CONCLUSIONS: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.

Correction: VNP20009-Abvec-Igκ-MIIP suppresses ovarian cancer progression by modulating Ras/MEK/ERK signaling pathway

Applied Microbiology and Biotechnology · 2025-09-16

Table S1 from The Risk of Type 2 Diabetes among Older Asian, Native Hawaiian, and Pacific Islander Colorectal Cancer Survivors: A Population-Based Study Using the SEER–Medicare Database

2025-06-03

<p>This table presents the counts of cases and corresponding person-years by race and ethnicity among the study population.</p>

An Anti–saliva contamination Bonding Strategy Based on Polycation Assembly

Journal of Dental Research · 2025-06-25 · 3 citations

The high incidence of saliva contamination is a real threat to dentin bonding that underpins contemporary preventive dentistry and clinical dentistry. Saliva contamination can form a nanoscale bacteria-contained adsorption film with high hydration on demineralized dentin matrix (DDM), worsening the insufficient adhesive infiltration into the DDM and causing bacteria load. The resultant bacteria-loaded hybrid layer with more defects aggravates the durability issue of dentin bonding that affects the oral health of billions of people worldwide. To address the issue of saliva contamination, a robust polycation assembly-assisted bonding strategy was developed based on the electrostatic adsorption of bactericidal polycations on the natural template of a 3-dimensional, porous, negatively charged DDM as well as the contaminated DDM to form a stable electrostatic complex via electrostatic adsorption. Both residual bacteria in the biofilm and bacteria from saliva were killed, and the hydrated DDM was dehydrated, causing the release of interface-confined water regardless of the presence of contamination, which greatly improved adhesive infiltration. More interesting, due to the charge reversal caused by polycation adsorption, the polycation/DDM complex actively adsorbed negatively charged saliva proteins continuously and formed a stable polycation/DDM/saliva protein complex, actively erasing the adverse effect of saliva contamination on dentin bonding. This is the first successful construction of a persistently antibacterial and defect-low hybrid layer under saliva contamination.

Ultraviolet‐Controlled Radical Dopants: Suppressing Unpredictable Oxidation and Lithium Migration in Perovskite Solar Cells

Angewandte Chemie International Edition · 2025-08-04 · 1 citations

Perovskite solar cells (PSCs) have achieved parity in efficiency with silicon-based solar cells. This dependency introduces stability challenges and complicates device fabrication due to the traditional air-oxidation doping process, which is time-consuming, unpredictable, and requires continuous monitoring of device variability. Here, we propose two triphenyl sulfonium (TPS) salts as UV-light-triggered radical-generating dopants for 2,2',7,7'-tetrakis [N,N-di(4-methoxyphenyl) amino]-9,9'-spirobifluorene(spiro-OMeTAD). These dopants eliminate the need for air-based oxidation, thereby simplifying fabrication while enhancing the electrical properties of spiro-OMeTAD through efficient p-type doping. Using this approach, we achieved a champion power conversion efficiency of 25.18%, surpassing the performance of traditional doping methods. Notably, PSCs incorporating TPS dopants and cost-effective silver top-electrodes demonstrated exceptional stability under various operational conditions. This work presents a scalable, cost-effective doping strategy that addresses critical stability-efficiency trade-offs in PSCs, positioning them as viable contenders for commercial renewable energy applications.

Table S2 from The Risk of Type 2 Diabetes among Older Asian, Native Hawaiian, and Pacific Islander Colorectal Cancer Survivors: A Population-Based Study Using the SEER–Medicare Database

2025-06-03

<p>This table displays the results of a sensitivity analysis supplementing the main results in Table 4.</p>