Yueming Li

About

Yueming Li, PhD, is a researcher at the Sloan Kettering Institute with a focus on the disease mechanisms of Cancer and Alzheimer’s disease, aiming to develop novel therapeutics for clinical use. His research encompasses basic and translational studies, including target identification and drug discovery, chemical biology, medicinal chemistry, biochemistry, enzymology, biophysics, structural biology, neurobiology, neuroinflammation, autophagy, protein aggregation, and clearance. Dr. Li's work involves developing agents that inhibit intramembrane proteases associated with cancer and exploring the links between inflammation and Alzheimer’s disease development. His contributions include advancing understanding of enzyme functions in disease contexts and utilizing nanotechnology for diagnosis. Dr. Li holds a PhD from the University of California Berkeley and is actively involved in leading a research lab dedicated to elucidating disease mechanisms and therapeutic development.

Research topics

• Internal medicine
• Biology
• Chemistry
• Medicine
• Immunology
• Food science
• Biochemistry
• Intensive care medicine
• Cell biology
• Chromatography

Selected publications

• The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

  Nature · 2020 · 383 citations

  Senior authorCorresponding
  DOI

• From defense to disease: IFITM3 in immunity and Alzheimer's disease

  Neurotherapeutics · 2024-11-08 · 12 citations

  reviewOpen accessSenior author

  Innate immunity protein interferon induced transmembrane protein 3 (IFITM3) is a transmembrane protein that has a wide array of functions, including in viral infections, Alzheimer's Disease (AD), and cancer. As an interferon stimulated gene (ISG), IFITM3's expression is upregulated by type-I, II, and III interferons. Moreover, the antiviral activity of IFITM3 is modulated by post-translational modifications. IFITM3 functions in innate immunity to disrupt viral fusion and entry to the plasma memb…

  PublisherDOI

• HuM195 and its single-chain variable fragment increase Aβ phagocytosis in microglia via elimination of CD33 inhibitory signaling

  Molecular Psychiatry · 2024-02-21 · 11 citations

  articleOpen accessSenior author
  PublisherOA PDFDOI

• Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders

  RSC Medicinal Chemistry · 2024-11-20 · 9 citations

  reviewOpen accessSenior authorCorresponding

  Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by the presence of extracellular amyloid plaques consisting of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau (pTau) protein in the brain. Genetic and animal studies strongly indicate that Aβ, tau and neuroinflammation play important roles in the pathogenesis of AD. Several staging models showed that NFTs correlated well with the disease progression. P…

  PublisherOA PDFDOI

• <i>In Situ</i> Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes

  ACS Chemical Biology · 2025-03-13 · 1 citations

  articleSenior authorCorresponding

  Tau aggregation plays a crucial role in the development of Alzheimer’s disease (AD). Developing specific techniques that can isolate pathogenic tau from brain tissue is important for understanding tauopathies and advancing targeted therapies. Here, we develop photoaffinity small molecular probes and a novel method for in situ tissue labeling and investigate their activity in interacting with tau in cells and AD patient brains. Based on the reported chemical structures of tau PET tracers, we desi…

  PublisherDOI

Recent grants

• NIH Grant R01AG026660

  NIH · $3.5M · 2017

• Substrate Feedback Mechanism of gamma-Secretase

  NIH · $2.1M · 2018–2023

• NIH Grant R01NS076117

  NIH · $2.8M · 2017

Frequent coauthors

• Eitan Wong

  Memorial Sloan Kettering Cancer Center

  55 shared

• Georgia Frost

  36 shared

• Shane A. Liddelow

  Neurosciences Institute

  34 shared

• Paul M. Mathews

  34 shared

• Robert J. Schneider

  University of Iowa Hospitals and Clinics

  33 shared

• Youssef Zaim Wadghiri

  33 shared

• Nicole M. Eskow

  New York University

  33 shared

• Ronald B. DeMattos

  Eli Lilly (United States)

  33 shared

Labs

• Yueming Li LabPI

Awards & honors

• BrightFocus Foundation Professional Services and Activities
• Cure Alzheimer's Fund Professional Services and Activities

Similar researchers at Cornell University

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• Omar Abdel-Wahabh-118
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