Yue Chen

About

Yue Chen, PhD, is an Associate Professor at the University of Minnesota Medical School, affiliated with the departments of Biochemistry, Molecular Biology & Biophysics. His long-term research goal is to discover and characterize novel posttranslational modification (PTM) pathways involved in protein homeostasis, cellular signaling, and epigenetic regulation. To achieve this, he develops and applies mass spectrometry-based quantitative and chemical proteomics technologies, along with bioinformatic analysis tools, for system-wide characterization of protein modification networks. His research employs both cellular and animal-based models to explore diverse biological applications, including cancer, metabolic diseases, nutrition, and aging. Dr. Chen's work focuses on understanding the roles of PTMs in various biological processes, contributing to the broader understanding of protein regulation and cellular function.

Research topics

• Internal medicine
• Virology
• Medicine

Selected publications

• Flexible circuits engineered for complex and extreme environments

  Soft Science · 2025-11-11 · 2 citations

  articleOpen access1st authorCorresponding

  Driven by the rising demand for mechanical adaptability, structural reconfigurability, and multifunctional integration, flexible circuits are gaining increasing importance in advanced electronic systems. They serve as key enablers for next-generation devices owing to their intrinsic mechanical compliance and stable electrical performance. In extreme environments, flexible circuits face severe reliability issues such as dielectric drift, interfacial delamination, crack propagation, and metal elec…

  PublisherOA PDFDOI

• FMEnets: Flow, Material, and Energy networks for non-ideal plug flow reactor design

  ArXiv.org · 2025-05-10

  preprintOpen access

  We propose FMEnets, a physics-informed machine learning framework for the design and analysis of non-ideal plug flow reactors. FMEnets integrates the fundamental governing equations (Navier-Stokes for fluid flow, material balance for reactive species transport, and energy balance for temperature distribution) into a unified multi-scale network model. The framework is composed of three interconnected sub-networks with independent optimizers that enable both forward and inverse problem-solving. In…

  PublisherOA PDFDOI

Recent grants

• NIH Grant R21HL098669

  NIH · $415k · 2013

• NIH Grant R21HL102597

  NIH · $415k · 2012

• NIH Grant R21HL098719

  NIH · $415k · 2013

Frequent coauthors

• John Fassett

  University of Graz

  364 shared

• Robert J. Bache

  321 shared

• Xin Xu

  Shanghai University of Sport

  311 shared

• Hongliang Li

  Beijing Tian Tan Hospital

  214 shared

• Zhongbing Lu

  University of Chinese Academy of Sciences

  202 shared

• Dongmin Kwak

  197 shared

• Xinli Hu

  Capital Medical University

  174 shared

• Ping Zhang

  160 shared

Labs

• Medical Discovery Team on AddictionPI

Awards & honors

• Dr. James E. Rubin Medical Memorial Award
• Graduating Medical Student Research Award
• Veneziale-Steer Award
• Dr. Marvin and Hadassah Bacaner Research Awards
• Schmidt Steer Award

Similar researchers at University of Minnesota

• Paul Robbinsh-126
• Robert Clarkeh-103
• Michael Freemanh-77