About

Young-Sun Lee is an Associate Professor of Psychology and Education at Teachers College, Columbia University. Her scholarly interests include psychometrics, specifically Classical Test Theory, Item Response Theory, and Cognitive Diagnosis Modeling, as well as educational and psychological measurement and applied statistics. She holds a Ph.D. in Educational Psychology with a focus on Educational Measurement & Statistics from the University of Wisconsin-Madison, earned in 2002, and both an M.A. and B.A. from Ewha Womans University in Seoul, South Korea. Her research and academic contributions focus on assessment and testing, with a particular emphasis on diagnostic classification models and their applications in educational measurement. She has co-edited the 'Handbook of Diagnostic Classification Models' and has authored numerous publications exploring the development, evaluation, and application of psychometric models in educational contexts. Lee is actively involved in teaching and mentoring students, with office hours by appointment, and is affiliated with the Human Development Measurement, Evaluation, and Statistics faculty at Teachers College.

Research topics

• Cell biology
• Chemistry
• Endocrinology
• Medicine
• Internal medicine
• Cancer research
• Biology

Selected publications

• Complete sequencing of ape genomes

  bioRxiv (Cold Spring Harbor Laboratory) · 2024 · 25 citations

  • Biology
  • Evolutionary biology
  • Genetics

  We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy (<1 error in 500,000 base pairs), completely sequencing 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights. Comparative analyses, including human, allow us to investigate the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference. This includes newly minted gene families within lineage-specific segmental duplications, centromeric DNA, acrocentric chromosomes, and subterminal heterochromatin. This resource should serve as a definitive baseline for all future evolutionary studies of humans and our closest living ape relatives.

  PublisherOA PDFDOI

• A resource of targeted mutant mouse lines for 5,061 genes

  Nature Genetics · 2021 · 111 citations

  • Biology
  • Genetics
  • Computational biology
  DOI

• Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration

  Frontiers in Cell and Developmental Biology · 2021 · 12 citations

  1st authorCorresponding
  • Cell biology
  • Biology
  • Endocrinology

  Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells. Insulin+glucagon+ double stained bihormonal cell levels and pancreatic and duodenal homeobox-1 expression were increased in mice treated with recombinant adenovirus-expressing BTC (rAd-BTC) and β-cell-ablated islet cells treated with BTC. In the islets of rAd-BTC-treated mice, both BrdU+glucagon+ and BrdU+insulin+ cell levels were significantly increased, with BrdU+glucagon+ cells showing the greater increase. Treatment of αTC1-9 cells with BTC significantly increased proliferation and cyclin D2 expression. BTC induced phosphorylation of ErbB receptors in αTC1-9 cells. The proliferative effect of BTC was mediated by ErbB-3 or ErbB-4 receptor kinase. BTC increased phosphorylation of ERK1/2, AKT, and mTOR and PC1/3 expression and GLP-1 production in α-cells, but BTC-induced proliferation was not changed by the GLP-1 receptor antagonist, exendin-9. We suggest that BTC has a direct role in α-cell proliferation via interaction with ErbB-3 and ErbB-4 receptors, and these increased α-cells might be a source of new β-cells.

  DOI

• Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia

  Circulation Research · 2020 · 57 citations

  • Biology
  • Cancer research
  • Cell biology

  RATIONALE: . Since proteins from all 3 HHT genes are components of signal transduction of TGF-β (transforming growth factor β) family members, it has been hypothesized that HHT is a disease caused by defects in the ENG-ALK1-SMAD4 linear signaling. However, in vivo evidence supporting this hypothesis is scarce. OBJECTIVE: We tested this hypothesis and investigated the therapeutic effects and potential risks of induced-ALK1 or -ENG overexpression (OE) for HHT. METHODS AND RESULTS: -iKO models. CONCLUSIONS: These data support the notion that ENG and ALK1 form a linear signaling pathway for the formation of a proper arteriovenous network during angiogenesis. We suggest that ALK1 OE or activation can be an effective therapeutic strategy for HHT. Further research is required to study whether this therapy could be translated into treatment for humans.

  DOI

• TMEM100 is a key factor for specification of lymphatic endothelial progenitors

  Angiogenesis · 2020 · 24 citations

  • Biology
  • Cell biology
  • Anatomy
  DOI

• Effect of urea cream on sorafenib-associated hand–foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study

  European Journal of Cancer · 2020 · 28 citations

  • Medicine
  • Internal medicine
  • Gastroenterology
  PublisherOA PDFDOI

Frequent coauthors

• Hee‐Sook Jun

  31 shared

• Gyun Jee Song

  Catholic Kwandong University

  6 shared

• Seungjin Shin

  CTI BioPharma (United States)

  5 shared

• Seong‐Su Moon

  Dongguk University WISE

  4 shared

• Minchul Seo

  Rural Development Administration

  4 shared

• Meng-Ju Liu

  Chung Yuan Christian University

  4 shared

• Mi-Sung Park

  Wonkwang University

  4 shared

• Kyeong-Hye Lim

  University of Ulsan

  3 shared

Education

• Ph.D., Educational Psychology (Educational Measurement & Statistics)

  University of Wisconsin-Madison

  2002

• M.A., Educational Measurement & Evaluation

  Ewha Womans University

  1995

• B.A., Education

  Ewha Womans University

  1992

Similar researchers at Columbia University

• Eric R. Kandelh-248
• René Henh-177
• Peter D Kwongh-176
• Lawrence Elliot Friedh-171
• Tom Maniatish-162