Yiyin Erin Chen
Massachusetts Institute of Technology · Biology
Active 1995–2024
About
Yiyin Erin Chen is a Professor of Life Sciences and a Core Member at the Broad Institute. Her research focuses on how microbes in the human body educate the immune system, with particular emphasis on the skin, the body's largest organ. She employs microbial genetics, immunologic approaches, and mouse models to dissect the molecular signals used by microbes to influence immune responses and how different microbial communities alter these responses. Her ultimate goal is to harness microbe-host interactions to engineer novel vaccines and therapeutics for human disease. Dr. Chen has received several awards, including the Howard Hughes Medical Institute Hanna H. Gray Fellowship (2018-2026), the A.P. Giannini Postdoctoral Research Fellowship (2018), and the Dermatology Foundation Research Fellowship (2017). Her notable contributions include research on skin microbiota-host interactions, bacterial cell cycle control, and microbial communication with the immune system, which have been published in prominent scientific journals.
Research topics
- Physics
- Nuclear physics
- Particle physics
- Astrophysics
- Quantum mechanics
- Computer Science
- Optics
- Geography
- Engineering
- Astronomy
- Algorithm
Selected publications
Review of top quark mass measurements in CMS
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 2025 · 8 citations
- Particle physics
- Physics
- Nuclear physics
The top quark mass is one of the most intriguing parameters of the standard model (SM). Its value indicates a Yukawa coupling close to unity, and the resulting strong ties to Higgs physics make the top quark mass a crucial ingredient for understanding essential aspects of the electroweak sector of the SM. This review offers the first comprehensive overview of the top quark mass measurements performed by the CMS Collaboration using the data collected at centre-of-mass energies of 7, 8, and 13 TeV. Moreover, a detailed description of the top quark event reconstruction is provided and dedicated studies of the dominant uncertainties in the modelling of the signal processes are discussed. The interpretation of the experimental results on the top quark mass in terms of the SM Lagrangian parameter is challenging and is a focus of an ongoing discussion in the theory community. The CMS Collaboration has performed two main types of top quark mass measurements, addressing this challenge from different perspectives: highly precise ‘direct’ measurements, based on reconstructed top quark decay products and relying exclusively on Monte-Carlo simulations, as well as ‘indirect’ measurements, where the simulations are employed to determine parton-level cross sections that are compared to fixed-order perturbative calculations. Recent mass extractions using Lorentz-boosted top quarks open a new avenue of measurements based on top quark decay products contained in a single particle jet, with promising prospects for accurate theoretical interpretations.
arXiv (Cornell University) · 2024 · 6 citations
- Physics
- Particle physics
- Nuclear physics
A bstract An inclusive search for long-lived exotic particles (LLPs) decaying to final states with a pair of muons is presented. The search uses data corresponding to an integrated luminosity of 36.6 fb − 1 collected by the CMS experiment from the proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13.6 TeV in 2022, the first year of Run 3 of the CERN LHC. The experimental signature is a pair of oppositely charged muons originating from a secondary vertex spatially separated from the proton-proton interaction point by distances ranging from several hundred μ m to several meters. The sensitivity of the search benefits from new triggers for displaced dimuons developed for Run 3. The results are interpreted in the framework of the hidden Abelian Higgs model, in which the Higgs boson decays to a pair of long-lived dark photons, and of an R -parity violating supersymmetry model, in which long-lived neutralinos decay to a pair of muons and a neutrino. The limits set on these models are the most stringent to date in wide regions of lifetimes for LLPs with masses larger than 10 GeV.
Model-independent search for pair production of new bosons decaying into muons in proton-proton collisions at $$ \sqrt{s} $$ = 13 TeV
arXiv (Cornell University) · 2024 · 2 citations
- Physics
- Particle physics
- Nuclear physics
A bstract The results of a model-independent search for the pair production of new bosons within a mass range of 0 . 21 < m < 60 GeV, are presented. This study utilizes events with a four-muon final state. We use two data sets, comprising 41 . 5 fb − 1 and 59 . 7 fb − 1 of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV, recorded in 2017 and 2018 by the CMS experiment at the CERN LHC. The study of the 2018 data set includes a search for displaced signatures of a new boson within the proper decay length range of 0 < cτ < 100 mm. Our results are combined with a previous CMS result, based on 35 . 9 fb − 1 of proton-proton collisions at $$ \sqrt{s} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 13 TeV collected in 2016. No significant deviation from the expected background is observed. Results are presented in terms of a model-independent upper limit on the product of cross section, branching fraction, and acceptance. The findings are interpreted across various benchmark models, such as an axion-like particle model, a vector portal model, the next-to-minimal supersymmetric standard model, and a dark supersymmetric scenario, including those predicting a non-negligible proper decay length of the new boson. In all considered scenarios, substantial portions of the parameter space are excluded, expanding upon prior results.
Physics Reports · 2024 · 9 citations
- Physics
- Particle physics
- Nuclear physics
The Large Hadron Collider at CERN, delivering proton-proton collisions at much higher energies and far higher luminosities than previous machines, has enabled a comprehensive programme of measurements of the standard model (SM) processes by the CMS experiment. These unprecedented capabilities facilitate precise measurements of the properties of a wide array of processes, the most fundamental being cross sections. The discovery of the Higgs boson and the measurement of its mass became the keystone of the SM. Knowledge of the mass of the Higgs boson allows precision comparisons of the predictions of the SM with the corresponding measurements. These measurements span the range from one of the most copious SM processes, the total inelastic cross section for proton-proton interactions, to the rarest ones, such as Higgs boson pair production. They cover the production of Higgs bosons, top quarks, single and multibosons, and hadronic jets. Associated parameters, such as coupling constants, are also measured. These cross section measurements can be pictured as a descending stairway, on which the lowest steps represent the rarest processes allowed by the SM, some never seen before.
Physical Review Letters · 2024 · 96 citations
- Physics
A search is reported for near-threshold structures in the J/ψJ/ψ invariant mass spectrum produced in proton-proton collisions at sqrt[s]=13 TeV from data collected by the CMS experiment, corresponding to an integrated luminosity of 135 fb^{-1}. Three structures are found, and a model with quantum interference among these structures provides a good description of the data. A new structure is observed with a local significance above 5 standard deviations at a mass of 6638_{-38}^{+43}(stat)_{-31}^{+16}(syst) MeV. Another structure with even higher significance is found at a mass of 6847_{-28}^{+44}(stat)_{-20}^{+48}(syst) MeV, which is consistent with the X(6900) resonance reported by the LHCb experiment and confirmed by the ATLAS experiment. Evidence for another new structure, with a local significance of 4.7 standard deviations, is found at a mass of 7134_{-25}^{+48}(stat)_{-15}^{+41}(syst) MeV. Results are also reported for a model without interference, which does not fit the data as well and shows mass shifts up to 150 MeV relative to the model with interference.
Search for exotic decays of the Higgs boson to a pair of pseudoscalars in the $\mu\mu$bb and $\tau\tau$bb final states
2024
- Physics
- Particle physics
- Nuclear physics
A search for exotic decays of the Higgs boson (H) with a mass of 125 GeV to a pair of light pseudoscalars $\mathrm{a}_1$ is performed in final states where one pseudoscalar decays to two b quarks and the other to a pair of muons or $\tau$ leptons. A data sample of proton-proton collisions at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 138 fb$^{-1}$ recorded with the CMS detector is analyzed. No statistically significant excess is observed over the standard model backgrounds. Upper limits are set at 95% confidence level (CL) on the Higgs boson branching fraction to $\mu\mu$bb and to $\tau\tau$bb, via a pair of $\mathrm{a}_1$s. The limits depend on the pseudoscalar mass $m_{\mathrm{a}_1}$ and are observed to be in the range (0.17-3.3) $\times$ 10$^{-4}$ and (1.7-7.7) $\times$ 10$^{2}$ in the $\mu\mu$bb and $\tau\tau$bb final states, respectively. In the framework of models with two Higgs doublets and a complex scalar singlet (2HDM+S), the results of the two final states are combined to determine model-independent upper limits on the branching fraction $\mathcal{B}$(H $\to$ $\mathrm{a}_1\mathrm{a}_1$ $\to$ $\ell\ell$bb) at 95% CL, with $\ell$ being a muon or a $\tau$ lepton. For different types of 2HDM+S, upper bounds on the branching fraction $\mathcal{B}$(H $\to$ $\mathrm{a}_1\mathrm{a}_1$) are extracted from the combination of the two channels. In most of the Type II 2HDM+S parameter space, $\mathcal{B}($H $\to$ $\mathrm{a}_1\mathrm{a}_1$) values above 0.23 are excluded at 95% CL for $m_{\mathrm{a}_1}$ values between 15 and 60 GeV.
Search for the decay of the Higgs boson to a pair of light pseudoscalar bosons in the final state with four bottom quarks in proton-proton collisions at $ \sqrt{\textrm{s}} $ = 13 TeV
2024
- Physics
- Particle physics
- Nuclear physics
A search is presented for the decay of the 125 GeV Higgs boson (H) to a pair of new light pseudoscalar bosons (a), followed by the prompt decay of each a boson to a bottom quark-antiquark pair, H $\to$ aa $\to$$\mathrm{b\bar{b}b\bar{b}}$. The analysis is performed using a data sample of proton-proton collisions collected with the CMS detector at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. To reduce the background from standard model processes, the search requires the Higgs boson to be produced in association with a leptonically decaying W or Z boson. The analysis probes the production of new light bosons in a 15 $\lt$$m_\mathrm{a}$$\lt$ 60 GeV mass range. Assuming the standard model predictions for the Higgs boson production cross sections for pp $\to$ WH and ZH, model independent upper limits at 95% confidence level are derived for the branching fraction $\mathcal{B}$(H $\to$ aa $\to$ $\mathrm{b\bar{b}b\bar{b}}$). The combined WH and ZH observed upper limit on the branching fraction ranges from 1.10 for $m_\mathrm{a} =$ 20 GeV to 0.36 for $m_\mathrm{a} =$ 60 GeV, complementing other measurements in the $\mu\mu\tau\tau$, $\tau\tau\tau\tau$ and bb$\ell\ell$ ($\ell=$ $\mu$,$\tau$) channels.
Dark sector searches with the CMS experiment
Physics Reports · 2024 · 22 citations
- Physics
- Particle physics
- Astrophysics
Astrophysical observations provide compelling evidence for gravitationally interacting dark matter in the universe that cannot be explained by the standard model of particle physics. The extraordinary amount of data from the CERN LHC presents a unique opportunity to shed light on the nature of dark matter at unprecedented collision energies. This Report comprehensively reviews the most recent searches with the CMS experiment for particles and interactions belonging to a dark sector and for dark-sector mediators. Models with invisible massive particles are probed by searches for signatures of missing transverse momentum recoiling against visible standard model particles. Searches for mediators are also conducted via fully visible final states. The results of these searches are compared with those obtained from direct-detection experiments. Searches for alternative scenarios predicting more complex dark sectors with multiple new particles and new forces are also presented. Many of these models include long-lived particles, which could manifest themselves with striking unconventional signatures with relatively small amounts of background. Searches for such particles are discussed and their impact on dark-sector scenarios is evaluated. Many results and interpretations have been newly obtained for this Report.
Physics Letters B · 2023 · 75 citations
- Computer Science
- Physics
- Algorithm
Measurements are presented of the Bs0→μ+μ− branching fraction and effective lifetime, as well as results of a search for the B0→μ+μ− decay in proton-proton collisions at s=13TeV at the LHC. The analysis is based on data collected with the CMS detector in 2016–2018 corresponding to an integrated luminosity of 140fb−1. The branching fraction of the Bs0→μ+μ− decay and the effective Bs0 meson lifetime are the most precise single measurements to date. No evidence for the B0→μ+μ− decay has been found. All results are found to be consistent with the standard model predictions and previous measurements.
arXiv (Cornell University) · 2023 · 2 citations
- Physics
- Particle physics
- Nuclear physics
Differential cross sections are measured for the standard model Higgs boson produced in association with vector bosons (W, Z) and decaying to a pair of b quarks. Measurements are performed within the framework of the simplified template cross sections. The analysis relies on the leptonic decays of the W and Z bosons, resulting in final states with 0, 1, or 2 electrons or muons. The Higgs boson candidates are either reconstructed from pairs of resolved b-tagged jets, or from single large distance parameter jets containing the particles arising from two b quarks. Proton-proton collision data at $\sqrt{s}$ = 13 TeV, collected by the CMS experiment in 2016-2018 and corresponding to a total integrated luminosity of 138 fb$^{-1}$, are analyzed. The inclusive signal strength, defined as the product of the observed production cross section and branching fraction relative to the standard model expectation, combining all analysis categories, is found to be $\mu$ = 1.15$^{+0.22}_{-0.20}$. This corresponds to an observed (expected) significance of 6.3 (5.6) standard deviations.
Frequent coauthors
- 1461 shared
M. Titov
Institut de Recherche sur les Lois Fondamentales de l'Univers
- 1459 shared
G. Hamel de Monchenault
Université Paris-Saclay
- 1378 shared
A. Rosowsky
Institut de Recherche sur les Lois Fondamentales de l'Univers
- 1337 shared
M. Besançon
CEA Paris-Saclay
- 1292 shared
F. Couderc
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- 1127 shared
M. Lethuillier
Institute of Nuclear Physics of Lyon
- 1110 shared
S. Malik
- 1105 shared
A. Meyer
Deutsches Elektronen-Synchrotron DESY
Labs
Yiyin Erin Chen LabPI
Education
- 2014
PhD, Physics
California Institute of Technology
- 2008
Bachelor
Massachusetts Institute of Technology
Awards & honors
- Howard Hughes Medical Institute Hanna H. Gray Fellow, 2018-2…
- A.P. Giannini Postdoctoral Research Fellowship, 2018
- Dermatology Foundation Research Fellowship, 2017
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