Yi-Hua Chen
· Professor, Pathology (Hematopathology)VerifiedNorthwestern University · Pathology
Active 2002–2024
About
Yi-Hua Chen is a Professor of Pathology and the Director of Hematopathology in the Department of Pathology at Northwestern University Feinberg School of Medicine. His professional focus includes hematopathology, and he is involved in research and clinical consultations within this specialty. As a faculty member, he contributes to the education and training of residents and fellows, and he is associated with the Robert H. Lurie Comprehensive Cancer Center. His work emphasizes the integration of pathology research with clinical practice, particularly in the areas related to hematologic diseases.
Research topics
- Biology
- Pathology
- Medicine
- Genetics
- Cancer research
- Immunology
- Gastroenterology
- Internal medicine
Selected publications
Leukemia & lymphoma/Leukemia and lymphoma · 2022 · 3 citations
- Cancer research
- Medicine
- Immunology
Human Pathology · 2021 · 31 citations
Senior authorCorresponding- Medicine
- Pathology
- Immunology
Information on bronchoalveolar lavage (BAL) in patients with COVID-19 is limited, and clinical correlation has not been reported. This study investigated the key features of BAL fluids from COVID-19 patients and assessed their clinical significance. A total of 320 BAL samples from 83 COVID-19 patients and 70 non-COVID-19 patients (27 patients with other respiratory viral infections) were evaluated, including cell count/differential, morphology, flow cytometric immunophenotyping, and immunohistochemistry. The findings were correlated with clinical outcomes. Compared to non-COVID-19 patients, BAL from COVID-19 patients was characterized by significant lymphocytosis (p < 0.001), in contrast to peripheral blood lymphopenia commonly observed in COVID-19 patients and the presence of atypical lymphocytes with plasmacytoid/plasmablastic features (p < 0.001). Flow cytometry and immunohistochemistry demonstrated that BAL lymphocytes, including plasmacytoid and plasmablastic cells, were composed predominantly of T cells with a mixture of CD4+ and CD8+ cells. Both populations had increased expression of T-cell activation markers, suggesting important roles of helper and cytotoxic T-cells in the immune response to SARS-CoV-2 infection in the lung. More importantly, BAL lymphocytosis was significantly associated with longer hospital stay (p < 0.05) and longer requirement for mechanical ventilation (p < 0.05), whereas the median atypical (activated) lymphocyte count was associated with shorter hospital stay (p < 0.05), shorter time on mechanical ventilation (p < 0.05) and improved survival. Our results indicate that BAL cellular analysis and morphologic findings provide additional important information for diagnostic and prognostic work-up, and potential new therapeutic strategies for patients with severe COVID-19.
Human Pathology · 2020 · 15 citations
- Biology
- Cancer research
- Pathology
Human Pathology · 2020 · 5 citations
Senior authorCorresponding- Biology
- Cancer research
- Immunology
Frequent coauthors
- 9 shared
Susan E. Crawford
Alberta Health Services
- 9 shared
Susan E. Gerber
Northwestern University
- 9 shared
Lisa P. Abramson
University of California, Davis
- 8 shared
Juehua Gao
Northwestern Memorial Hospital
- 4 shared
LoAnn C. Peterson
Northwestern University
- 4 shared
Kristy Wolniak
Northwestern Memorial Hospital
- 4 shared
Madina Sukhanova
Northwestern Memorial Hospital
- 4 shared
Charles L. Goolsby
Education
M.D.
Northwestern University Feinberg School of Medicine
B.S.
University of California, Berkeley
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